Evidence map›Paper›PMID 40889295›Full record

ArticleEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2025

Controversy: the blanking period after atrial fibrillation ablation is needed and should be maintained.

Helmut Pürerfellner, Stylianos Tzeis, John Mandrola

Abstract read
In one paragraph

Article in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pulsed field ablation for the interventional treatment of atrial fibrillation: a scientific statement of the European Heart Rhythm Association of the European Society of Cardiology, the Heart Rhythm Society, the Asia Pacific Heart Rhythm Society, the Latin American Heart Rhythm Society, and the Canadian Heart Rhythm Society.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Guideline
  2. Early recurrence of atrial tachyarrhythmia after catheter ablation and its associations with clinical outcomes, atrial fibrillation burden, and blanking period duration: a post hoc analysis of the CABANA trial.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Trial
  3. Comparison of the effectiveness and safety of dronedarone and amiodarone for preventing recurrence after catheter ablation of atrial fibrillation: an open-label randomized controlled trial.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Trial
  4. Colchicine initiated before radiofrequency-induced injury attenuates left atrial inflammation, fibrosis, and susceptibility to atrial fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  5. Article
  6. Review
  7. Single-shot ablation for AF: Real-world procedural and one-year outcomes with the newly adopted PulseSelect PFA compared with cryoballoon from the 1STOP project.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Article
  8. Early recurrence after pulsed field ablation: a prognostic signal that challenges, but does not eliminate, the blanking period.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  9. The blanking interval after atrial fibrillation ablation: time for reassessment with pulsed field energy-Authors' reply.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  10. Article
  11. Article
  12. Pulsed field ablation vs. thermal ablation for pulmonary vein isolation: a network meta-analysis of randomized controlled trials.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  13. Circulating miR-10b-5p as a candidate biomarker of atrial fibrillation recurrence after catheter ablation: a two-phase translational study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  14. Pulsed field ablation for atrial fibrillation in patients with heart failure: insight from the ATHENA registrys.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  15. The blanking interval after atrial fibrillation ablation: time for reassessment with pulsed field energy.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Helmut PürerfellnerOrdensklinikum Linz Elisabethinen, Department of Cardiology, Fadingerstr. 1, A-4010 Linz, Austria.ORCID 0000-0002-8965-8495
Stylianos TzeisDepartment of Cardiology, Mitera Hospital, Athens, Greece.ORCID 0000-0002-2007-1928
John MandrolaCardiac Electrophysiology, Baptist Health, Louisville, KY, USA.ORCID 0000-0001-5093-9946

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The concept of a post-ablation 'blanking period' (typically 90 days) has long served as a clinical and regulatory buffer during which atrial arrhythmia recurrences are not considered indicative of procedural failure. This period was originally justified by transient electrophysiological instability due to oedema, inflammation, and autonomic fluctuations. However, recent data-particularly in the era of continuous rhythm monitoring and novel energy sources such as pulsed field ablation-have challenged the biological and prognostic neutrality of early recurrences. Several studies now suggest that arrhythmia episodes within the blanking period, especially beyond the first 30 days, may strongly predict long-term recurrence, thereby questioning the utility of maintaining a fixed observational window. This EP Europace Controversy article presents opposing viewpoints on the necessity of the blanking period in modern practice. Dr Stelios Tzeis argues in favour of preserving the blanking period, citing its role in minimizing unnecessary re-intervention and ensuring standardized trial endpoints. Conversely, Dr John Mandrola advocates for shortening or abandoning the blanking period, proposing a more individualized approach guided by arrhythmia timing, symptom burden, and ablation modality. The introduction, authored by Prof. Helmut Pürerfellner, sets the stage by reviewing the historical rationale, emerging evidence, and practical implications of this ongoing debate. As ablation techniques evolve and data accrue, reassessing the blanking period becomes essential. This Controversy aims to inform clinical practice, future trial design, and shared decision-making by juxtaposing two expert perspectives on a timely and consequential topic in atrial fibrillation management.

Indexed as

Atrial FibrillationCatheter AblationHumansRecurrenceTime FactorsTreatment OutcomeAblationAtrial fibrillationBlanking periodPulsed field ablationRecurrences

Identifiers

PMID40889295
PMCPMC12503109

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.