ArticleeLife2025
Automatic and accurate reconstruction of long-range axonal projections of single-neuron in mouse brain.
Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- A quantitative and precision‑oriented neuronal reconstruction approach based on data grading.Brain informatics · 2026Article
- SegAnyNeuron: a neural image segmentation network with strong generalization performance by modeling image intensity variation.Brain informatics · 2026Article
- Reconstruction of Axonal Projections of Single Neurons Using PointTree.Bio-protocol · 2026Article
- Modeling 3D mesoscaled neuronal complexity through learning-based dynamic morphometric convolution.Brain informatics · 2026Article
- Constructing the spatiotemporal atlas of single-cell lineage trajectories in stereotypic biological structures.iScience · 2026Article
- Automatic and accurate reconstruction of long-range axonal projections of single-neuron in mouse brain.eLife · 2025Article
- A neuronal imaging dataset for deep learning in the reconstruction of single-neuron axons.Frontiers in neuroinformatics · 2025Article
- Activity-dependent refinement of axonal projections forms one-to-one connection pattern in the developing chick ciliary ganglion.Frontiers in cellular neuroscience · 2025Article
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Authors and funding
13 authors.
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Abstract
Single-neuron axonal projections reveal the route map of neuron output and provide a key cue for understanding how information flows across the brain. Reconstruction of single-neuron axonal projections requires intensive manual operations in tens of terabytes of brain imaging data and is highly time-consuming and labor-intensive. The main issue lies in the need for precise reconstruction algorithms to avoid reconstruction errors, yet current methods struggle with densely distributed axons, focusing mainly on skeleton extraction. To overcome this, we introduce a point assignment-based method that uses cylindrical point sets to accurately represent axons and a minimal information flow tree model to suppress the snowball effect of reconstruction errors. Our method successfully reconstructs single-neuron axonal projections across hundreds of GBs (Gigabytes) images within a mouse brain with an average of 80% f1-score, while current methods only provide less than 40% f1-score reconstructions from a few hundred MBs (Megabytes) images. This huge improvement is helpful for high-throughput mapping of neuron projections.
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Registered trials
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