Evidence map›Paper›PMID 40889134›Full record

ArticleFuture cardiology2025

TNF-α inhibitor therapy and prosthetic aortic valve endocarditis: a case report.

Raksheeth Agarwal, Shreyas Yakkali, Antony Gonzales-Uribe, Nachum Lebovics, Robert J Morgan, Ephraim Leiderman, Aubrey Galloway, Daniel J Lerner

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Future cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Raksheeth AgarwalDepartment of Medicine, New York City Health + Hospitals/Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY, USA.ORCID 0000-0003-4045-2784
Shreyas YakkaliDepartment of Medicine, New York City Health + Hospitals/Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY, USA.ORCID 0000-0001-7270-7070
Antony Gonzales-UribeDepartment of Medicine, New York City Health + Hospitals/Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY, USA.ORCID 0000-0001-5068-9596
Nachum LebovicsDepartment of Medicine, New York City Health + Hospitals/Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY, USA.
Robert J MorganDivision of Cardiology, Department of Medicine, New York City Health + Hospitals/Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, New York, NY, USA.ORCID 0000-0002-6651-4739
Ephraim LeidermanDivision of Cardiology, Department of Medicine, New York City Health + Hospitals/Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, New York, NY, USA.
Aubrey GallowayDepartment of Cardiothoracic Surgery, NYU Grossman School of Medicine, New York, NY, USA.ORCID 0000-0001-5461-3820
Daniel J LernerDivision of Cardiology, Department of Medicine, New York City Health + Hospitals/Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, New York, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor necrosis factor-alpha (TNF-α) inhibitors and other biologics used for autoimmune diseases are associated with low-grade immunosuppression. Treatment with these and the presence of prosthetic mechanical cardiac valves both increase the risk of infective endocarditis (IE). However, evidence on the risk of prosthetic valve endocarditis (PVE) among patients treated with TNF-α inhibitors is limited. This study reports a 41-year-old man with a prosthetic aortic valve who was on treatment with golimumab and presented with low-grade fevers and positive blood cultures for

Indexed as

Antibodies, MonoclonalAortic ValveEndocarditis, BacterialHeart Valve ProsthesisProsthesis-Related InfectionsStaphylococcal InfectionsTumor Necrosis Factor-alphaAdultEchocardiography, TransesophagealHumansMaleStaphylococcus epidermidisAntibodies, MonoclonalgolimumabTumor Necrosis Factor-alphainfective endocarditisprosthetic aortic valvesurgical aortic valve replacementtransesophageal echocardiographyTumor necrosis alpha inhibitors

Identifiers

PMID40889134
PMCPMC12758253

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.