Evidence map›Paper›PMID 40889100›Full record

ArticleClinical journal of gastroenterology2026

Metachronic development of cholangiocarcinoma during treatment for IgG4-related sclerosing cholangitis.

Kosaku Morimoto, Kazuyuki Matsumoto, Takaki Okuyama, Shogo Kimura, Kensuke Takei, Takuya Satomi, Tsuyoshi Okada, Susumu Shinoura, Rei Shibata, Ryuta Takenaka

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Clinical journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kosaku MorimotoDepartment of Internal Medicine, Tsuyama Chuo Hospital, Tsuyama, Japan.
Kazuyuki MatsumotoDepartment of Gastroenterology and Hepatology, Okayama University Hospital, 2-5-1 Shikata-cho, Okayama City, 700-8558, Japan. matsumoto.k@okayama-u.ac.jp.ORCID http://orcid.org/0000-0002-5102-7452
Takaki OkuyamaDepartment of Internal Medicine, Tsuyama Chuo Hospital, Tsuyama, Japan.
Shogo KimuraDepartment of Internal Medicine, Tsuyama Chuo Hospital, Tsuyama, Japan.
Kensuke TakeiDepartment of Internal Medicine, Tsuyama Chuo Hospital, Tsuyama, Japan.
Takuya SatomiDepartment of Internal Medicine, Tsuyama Chuo Hospital, Tsuyama, Japan.
Tsuyoshi OkadaDepartment of Surgery, Tsuyama Chuo Hospital, Tsuyama, Japan.
Susumu ShinouraDepartment of Surgery, Tsuyama Chuo Hospital, Tsuyama, Japan.
Rei ShibataDepartment of Diagnostic Pathology, Tsuyama Chuo Hospital, Tsuyama, Japan.
Ryuta TakenakaDepartment of Internal Medicine, Tsuyama Chuo Hospital, Tsuyama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of obstructive jaundice due to recurrent distal biliary stricture during 3 years of treatment for immunoglobulin G4 (IgG4)-related sclerosing cholangitis (IgG4-SC) associated with autoimmune pancreatitis. Although a relapse of IgG4-SC was initially suspected, imaging findings, laboratory tests, and histopathological examinations led to the diagnosis of metachronous cholangiocarcinoma. The patient underwent pancreaticoduodenectomy, and no cancer recurrence was noted 6 months postoperatively. Distal cholangiocarcinoma and IgG4-SC remission were observed in the resected specimen. In patients with recurrent biliary strictures during IgG4-SC treatment, comprehensive evaluations are essential because of the risk of disease relapse and development of metachronous cholangiocarcinoma.

Indexed as

Bile Duct NeoplasmsBile Ducts, IntrahepaticCholangiocarcinomaCholangitis, SclerosingImmunoglobulin GImmunoglobulin G4-Related DiseaseNeoplasms, Second PrimaryAgedAutoimmune PancreatitisFemaleHumansJaundice, ObstructiveMaleMiddle AgedPancreaticoduodenectomyImmunoglobulin GAutoimmune pancreatitisCholangiocarcinomaIgG4-related sclerosing cholangitisMetachronous carcinogenesis

Identifiers

PMID40889100

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.