ArticleBiological trace element research2026
Bismuth Oxide Nanoparticles-Induced Subclinical Nephrotoxicity in Male Mice: Role of Oxidative Stress and Apoptosis.
Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Bismuth Oxide Nanoparticles-Induced Subclinical Nephrotoxicity in Male Mice: Role of Oxidative Stress and Apoptosis.Biological trace element research · 2026Article
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Authors and funding
9 authors.
Funding
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Abstract
Bismuth's unique properties have led to its widespread use in medical, cosmetic, and electronic applications. However, increasing evidence suggests potential toxicity, particularly from nanoparticle forms that may accumulate in organs. This study investigated the nephrotoxic effects of bismuth oxide nanoparticles (Bi₂O₃ NPs) in male NMRI mice, focusing on underlying molecular mechanisms. Adult mice were divided into control and experimental groups receiving 25-800 mg/kg Bi₂O₃ NPs via oral gavage for 30 days. Kidney function was assessed through serum urea and creatinine measurements. Gene expression analysis evaluated apoptosis markers (Bcl2, Bax, Casp3) and oxidative stress pathways (Nrf2, Hmox1) using RT-PCR. Histopathological examination assessed renal tissue alterations. Results revealed no significant changes in serum urea or creatinine levels. Molecular analysis revealed significant gene alterations: Bax (5.969-fold, p = 0.008) and Casp3 (5.568-fold, p = 0.007) upregulation, alongside Bcl2 downregulation (0.239-fold, p = 0.039), indicating apoptosis. Nrf2 (9.569-fold, p = 0.002) and Hmox1 (4.993-fold, p = 0.039) induction confirmed oxidative stress. Data demonstrate Bi₂O₃ NPs trigger apoptosis and oxidative stress. Histological examination revealed glomerular volume increased to 4.79 ± 0.22 mm
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Registered trials
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