ReviewInflammopharmacology2025
Unlocking therapeutic potential in traumatic brain injury: exploring microenvironmental targets, signaling pathways and translational hurdles.
Review in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Post-Translational Modifications in Traumatic Brain Injury: Decoding the Proteomic Landscape and Molecular Mechanisms of Secondary Injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Astrocyte-Microglia Crosstalk in Post-Hemorrhagic Neurovascular Microenvironment: Mechanistic Nodes, Cross-Stroke Comparisons, and Therapeutic Reprogramming.Translational stroke research · 2026Review
- Nose-to-brain delivery of candesartan-loaded nanoemulsion: brain biodistribution and neurobehavioral outcomes in controlled cortical impact-induced traumatic brain injury.Inflammopharmacology · 2026Article
- Cytokines and related signaling pathways in traumatic brain injury.Frontiers in immunology · 2026Review
- Mitochondrial and ER stress crosstalk in TBI: mechanistic insights and therapeutic opportunities.Frontiers in cellular neuroscience · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traumatic brain injury (TBI) is a catastrophic event resulting from external mechanical forces, leading to a variety of neurological impairments. The complexity and heterogeneity of injuries are among the major speculated reasons for various unmet clinical needs in the effective management of TBI. Brain damage due to TBI results in both primary and secondary injury mechanisms. The complicated molecular pathophysiological alterations of TBI involving oxidative stress, neuroinflammation, excitotoxicity, and apoptosis emphasize the need for a greater understanding of the various signaling pathways that enable the appropriate application of multiple therapeutics for TBI management. This review delves into the multifaceted nature of TBI, involving the pathophysiology and various microenvironmental alterations that occur in TBI. In addition, different signaling pathways implicated in TBI have been elaborated in detail, including their role in TBI progression. The various potential targeting moieties that mitigate the TBI progression have been discussed. The existing clinical status of TBI therapeutics and their translational hurdles, as well as emerging advances in TBI therapy, have been comprehensively addressed.
Indexed as
Identifiers
40889011What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.