Orange peel extract and hesperidin attenuate myeloperoxidase activity and oxidative stress in vitro, with anti-inflammatory effects in vivo: a natural approach to gingival protection.

Tinhinane Rekeb, Samia Bedouhene, Nassima Senani, Sahra-Amel Belambri, Meriem-Dehbia Chabane, Kahina Ladj, Riadh Ksouri, Pham My-Chan Dang, Jamel El Benna

Abstract read

PubMed Publisher

In one paragraph

Article in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tinhinane RekebLaboratory for Analytical Biochemistry and Biotechnology, MouloudMammeri University of Tizi-Ouzou, 1500, Tizi-Ouzou, Algeria.

Samia BedouheneLaboratory for Analytical Biochemistry and Biotechnology, MouloudMammeri University of Tizi-Ouzou, 1500, Tizi-Ouzou, Algeria. samia.bedouhene@ummto.dz.ORCID http://orcid.org/0000-0002-5486-714X

Nassima SenaniLaboratory for Analytical Biochemistry and Biotechnology, MouloudMammeri University of Tizi-Ouzou, 1500, Tizi-Ouzou, Algeria.

Sahra-Amel BelambriLaboratoire de Biochimie Appliquée, Département de Biochimie, Faculté Des Sciences de La Nature Et de La Vie, Université Ferhat Abbes 1, Sétif, Algeria.

Meriem-Dehbia ChabaneLaboratory for Analytical Biochemistry and Biotechnology, MouloudMammeri University of Tizi-Ouzou, 1500, Tizi-Ouzou, Algeria.

Kahina LadjLaboratory of Biomathematics, Biochemistry, Biophysics and Scientometry, Faculty of Natural and Life Sciences, University of Bejaia, 06000, Bejaia, Algeria.

Riadh KsouriLaboratory of Aromatic and Medicinal Plants, Biotechnology Center of Borj-Cédria, Borj-Cédria, Tunisia.

Pham My-Chan DangCentre de Recherche Sur L'Inflammation, Laboratoire d'Excellence Inflamex, Faculté de Médecine Xavier Bichat, Université de Paris INSERM U1149, CNRS EMR 8252, 75018, Paris, France.

Jamel El BennaCentre de Recherche Sur L'Inflammation, Laboratoire d'Excellence Inflamex, Faculté de Médecine Xavier Bichat, Université de Paris INSERM U1149, CNRS EMR 8252, 75018, Paris, France.

Funding

DGRSDT PRFU project (D01N01UN1501202300002/2023).

6 · The paper itself

Abstract

Periodontal inflammation, such as gingivitis, involves neutrophil infiltration and elevated myeloperoxidase (MPO) activity, leading to excessive reactive oxygen species (ROS) that damage cellular structures, including proteins and lipids. In the oral cavity, oxidative stress may worsen due to local iron release from microbleeding, promoting tissue destruction and gingival recession. This study evaluated the protective effects of orange peel aqueous extract (OPE) and hesperidin (HSP) against iron-induced oxidative damage in human plasma. Additionally, it investigated their in vitro and in vivo anti-inflammatory effects upstream, via inhibition of neutrophil degranulation, and downstream, by reducing MPO activity released in saliva and in an acute inflammation model (λ-carrageenan-induced paw edema in rats). OPE and HSP attenuated FeSO

Indexed as

Anti-Inflammatory AgentsCitrus sinensisHesperidinOxidative StressPeroxidasePlant ExtractsAnimalsAntioxidantsEdemaGingivaGingivitisHumansInflammationLipid PeroxidationMaleNeutrophilsAnti-Inflammatory AgentsAntioxidantsHesperidinPeroxidasePlant ExtractsReactive Oxygen SpeciesHesperidinMyeloperoxidaseOrange peel extractOxidative stressPaw edemaPeriodontal inflammation

Identifiers

PMID40889009

DOI10.1016/j.phymed.2018.08.002

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.