Trial reportInternational ophthalmology2025
Optimizing the water drinking test: evaluating the reproducibility and validity of a shortened protocol: a randomized prospective trial.
Trial report in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
10 authors.
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Abstract
purposeThis study aimed to evaluate a a shortened Water drinking test (WDT) protocol and explore potential factors of patient characteristics such as body mass index (BMI) or Body Surface Area (BSA).
methodsThis was a prospective, randomized study comparing two validated WDT dosage regimens: 10 mL/kg and a fixed 800 mL intake. Patients were randomly assigned to one of the two groups. The initial 30 min IOP response was compared to the full 60 min test to assess correlation and predictive value. Additionally, the effect of BMI or BSA on IOP dynamics was investigated.
resultsOf the 100 enrolled patients, 90 were randomized and the final analysis included 45 patients in the 800 mL group and 35 in the 10 mL/kg group. No significant differences were found between groups in demographic, systemic, or ocular characteristics. The WDT showed strong reproducibility, with high correlations between the 30 min and 60 min tests (r = 0.89, p < 0.001). On the contrary, BMI (r = 0.12, p = 0.26) and BSA (r = 0.16,p = 0.14) had weak correlations with IOP response.
conclusionThe 30 min WDT is a reproducible and reliable method for assessing IOP fluctuations, offering a practical alternative to the full 60 min protocol. BMI and BSA had weak correlations with IOP response, suggesting that adjusting WDT outcomes based on BMI or BSA may be unnecessary.
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