Evidence map›Paper›PMID 40888993›Full record

ReviewInternational journal of clinical oncology2025

Epidermal growth factor receptor inhibitor-related skin toxicities: a review of management and possible preventive and therapeutic approaches for Asian patients by the Japanese Pharmacist-led Oncodermatology Study Team.

Yohei Iimura, Hirotoshi Iihara, Yoshitaka Saito, Hisanaga Nomura, Takuya Iwamoto, Mayumi Kotera, Yusuke Tsuchiya, Tatsuya Sumiya, Mariko Kono, Daisuke Hirate and 7 more

Abstract readReview
In one paragraph

Review in International journal of clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yohei IimuraDepartment of Pharmacy, The IMSUT Hospital, The Institute of Medical Science, The University of Tokyo, 4-6-1Minato-Ku, Shirokanedai, Tokyo, 108-8639, Japan. youhei0519@g.ecc.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0002-3473-8244
Hirotoshi IiharaDepartment of Pharmacy, Gifu University Hospital, Gifu, Japan.
Yoshitaka SaitoDepartment of Clinical Pharmaceutics & Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, Sapporo, Japan.
Hisanaga NomuraDepartment of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan.
Takuya IwamotoDepartment of Pharmacy, Mie University Hospital, Tsu, Japan.
Mayumi KoteraDepartment of Pharmacy, Mie University Hospital, Tsu, Japan.
Yusuke TsuchiyaDepartment of Pharmacy, Ageo Central General Hospital, Saitama, Japan.
Tatsuya SumiyaDepartment of Pharmacy, Yokohama City Minato Red Cross Hospital, Yokohama, Japan.
Mariko KonoDepartment of Pharmacy, Tokyo Metropolitan Police Hospital, Tokyo, Japan.
Daisuke HirateDepartment of Pharmacy, Teine Keijinkai Hospital, Tokyo, Japan.
Tomohiro KurokawaDepartment of Surgery, Jyoban Hospital of Tokiwa Foundation, Fukushima, Japan.
Toshinobu HayashiDepartment of Emergency and Disaster Medical Pharmacy, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
Hironobu HashimotoDepartment of Pharmacy, National Cancer Center Hospital, Tokyo, Japan.
Junichi HiguchiDepartment of Pharmacy, Ohara Healthcare Foundation Kurashiki Central Hospital, Okayama, Japan.
Ryuta UrakawaDepartment of Pharmacy, The University of Osaka Dental Hospital, Osaka, Japan.
Hiroyuki SaotomeDepartment of Pharmacy, Jyoban Hospital, Public Interest Foundation Tokiwakai, Fukushima, Japan.
Seiichiro KurodaDepartment of Pharmacy, The IMSUT Hospital, The Institute of Medical Science, The University of Tokyo, 4-6-1Minato-Ku, Shirokanedai, Tokyo, 108-8639, Japan.

Funding

Japan Agency for Medical Reseach 24ck0106978h0001
6 · The paper itself

Abstract

Epidermal growth factor receptor antibodies and tyrosine kinase inhibitors cause various skin toxicities. Acneiform rash, paronychia, and pruritus are the major side effects, and their incidence is high, especially in Asian patients. These skin disorders greatly reduce the patients' quality of life and can affect treatment intensity. As the incidence and severity of these skin toxicities correlate with treatment effects, adequate management during the treatment period is essential. Guidelines and treatment recommendations exist for epidermal growth factor receptor inhibitor-related skin toxicities. However, there have been no previous reviews of studies on Asian patients. In this review, we discuss the possible preventive and therapeutic recommendations for Asian patients. We derived recommendations based on evidence from Asian patients. This review will contribute to the management of these toxicities in Asian populations.

Indexed as

Antineoplastic AgentsDrug EruptionsErbB ReceptorsNeoplasmsProtein Kinase InhibitorsSkin DiseasesEast Asian PeopleHumansJapanPharmacistsAntineoplastic AgentsEGFR protein, humanErbB ReceptorsProtein Kinase InhibitorsAcneiform rashAsiaEGFR inhibitorParonychiaPruritusSupportive care

Identifiers

PMID40888993
PMCPMC12568918

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.