Evidence map›Paper›PMID 40888938›Full record

Trial reportClinical oral investigations2025

A comparative assessment of orthodontically induced root resorption and alveolar bone changes in adolescent orthodontic patients undergoing Micro-Osteoperforations assisted canine retraction: A Split-Mouth randomized controlled trial.

Deepanshi Yadav, Puneet Batra, Aditya Talwar, Saurabh Sonar, Amit Srivastava

Abstract readRandomized Controlled TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Deepanshi YadavDepartment of Orthodontics and Dentofacial Orthopedics, DJ Dental College, Modinagar, India.
Puneet BatraDepartment of Orthodontics and Dentofacial Orthopedics, Manav Rachna Dental College, Faridabad, India.ORCID http://orcid.org/0000-0003-4201-4235
Aditya TalwarDepartment of Orthodontics and Dentofacial Orthopedics, Manav Rachna Dental College, Faridabad, India. dradityatalwar@gmail.com.ORCID http://orcid.org/0000-0001-6462-4240
Saurabh SonarDepartment of Orthodontics and Dentofacial Orthopedics, Manav Rachna Dental College, Faridabad, India.
Amit SrivastavaITS Dental College, Greater, Noida, India.ORCID http://orcid.org/0000-0003-3135-8200

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMicro-osteoperforation (MOP) is a minimally invasive technique aimed at accelerating orthodontic tooth movement (OTM) by stimulating localised bone remodelling. However, its impact on root resorption, alveolar bone levels, and inflammatory mediators such as interleukin-4 (IL-4) requires further investigation. This study assessed root resorption, alveolar bone changes, canine angulation, rate of retraction, and IL-4 expression associated with MOP-assisted canine retraction.

methodsA randomised split-mouth controlled clinical trial was conducted on 20 patients (mean age: 19.70 ± 2.38 years). Patients were randomised according to the SNOSE criteria, with one side receiving MOPs distal to the canine; the contralateral side served as control for both maxillary and mandibular dentition. Retraction was performed using 9 mm NiTi closed coil springs with 150 g force for 7.6 ± 1.2 months. Pre- and post-retraction CBCT scans evaluated linear root resorption and alveolar bone changes. Digital models assessed canine movement and angulation. Gingival crevicular fluid was collected at four intervals and analyzed for IL-4 using ELISA.

resultsMaxillary and mandibular canines showed relatively greater root resorption (1.03 mm and 0.57 mm, respectively) and crestal bone loss (0.893 mm and 0.56 mm, respectively) on the MOP side (p < 0.05). The rate of canine retraction was higher with MOP (maxilla: 1.28 ± 0.17 mm/month; mandible: 1.36 ± 0.16 mm/month) compared to control (p < 0.001) with increased canine tipping noted on MOP side. IL-4 levels showed a transient decline post-MOP, recovering by day 28.

conclusionsMOP effectively accelerates OTM but increases the risk of root and alveolar bone resorption. The associated reduction in IL-4 may contribute to enhanced osteoclastic activity. Clinical application should be case-dependent, with caution in patients at risk of periodontal or root compromise.

Indexed as

Alveolar Bone LossAlveolar ProcessCuspidRoot ResorptionTooth Movement TechniquesAdolescentCone-Beam Computed TomographyEnzyme-Linked Immunosorbent AssayFemaleGingival Crevicular FluidHumansInterleukin-4MaleYoung AdultInterleukin-4Accelerated orthodonticsAlveolar bone remodelingCBCTIL-4Micro-osteoperforationOrthodontic tooth movementRoot resorption

Identifiers

PMID40888938

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.