Evidence map›Paper›PMID 40888895›Full record

ArticleCell and tissue research2025

Differential expression of villin and advillin by neuroendocrine and tuft cells in the murine lower airways.

Wafaa Mahmoud, Alexander Perniss, Krupali Poharkar, Maryam Keshavarz, Ulrich Gärtner, Johannes Oberwinkler, Burkhard Schütz, Thomas Worzfeld, Stefan Offermanns, Wolfgang Kummer

Abstract read
In one paragraph

Article in Cell and tissue research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wafaa Mahmoud *Institute for Anatomy and Cell Biology, German Center for Lung Research, Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus Liebig University Giessen, 35392, Giessen, Germany.
Alexander Perniss *Institute for Anatomy and Cell Biology, German Center for Lung Research, Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus Liebig University Giessen, 35392, Giessen, Germany. Aperniss@bwh.harvard.edu.
Krupali PoharkarInstitute for Anatomy and Cell Biology, German Center for Lung Research, Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus Liebig University Giessen, 35392, Giessen, Germany.
Maryam KeshavarzInstitute for Anatomy and Cell Biology, German Center for Lung Research, Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus Liebig University Giessen, 35392, Giessen, Germany.
Ulrich GärtnerInstitute for Anatomy and Cell Biology, Justus Liebig University Giessen, 35392, Giessen, Germany.
Johannes OberwinklerInstitut Für Physiologie Und Pathophysiologie, Philipps-Universität Marburg, Marburg, Germany.
Burkhard SchützInstitute of Anatomy and Cell Biology, Philipps-University, 35037, Marburg, Germany.
Thomas WorzfeldInstitute of Pharmacology, Philipps-University Marburg, 35043, Marburg, Germany.
Stefan OffermannsMax-Planck-Institute for Heart and Lung Research, Excellence Cluster Cardio-Pulmonary Institute (CPI), 61231, Bad Nauheim, Germany.
Wolfgang KummerInstitute for Anatomy and Cell Biology, German Center for Lung Research, Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus Liebig University Giessen, 35392, Giessen, Germany.

Funding

Cardio-Pulmonary Institute EXC 147Deutsche Forschungsgemeinschaft DFG SFB-TR84, project A6Deutsche Forschungsgemeinschaft SCHU1259/10Deutsches Zentrum für Lungenforschung DZL ALI-1.1
6 · The paper itself

Abstract

Previous studies identified a rare cell type in the mouse tracheal epithelium with immunoreactivity to the microvillus protein villin (Vil1), which persisted in mice lacking tuft cells due to deletion of the transcription factor Pou2f3. This study aimed to clarify the identity of this ill-defined cell type. Ultrastructurally, all cells with tightly packed microvilli observed in the tracheal epithelium of Pou2f3

Indexed as

Microfilament ProteinsNeuroendocrine CellsTracheaAnimalsMiceMice, Inbred C57BLTuft CellsMicrofilament ProteinsvillinAdvillinBrush cellsNeuroendocrine cellsTuft cellsVillin

Identifiers

PMID40888895
PMCPMC12484096

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.