Evidence map›Paper›PMID 40888887›Full record

ArticleMedical molecular morphology2026

Fascin-1 expression is associated with EMT and recurrence in thymic carcinoma: a clinicopathologic study.

Hironobu Okada, Yoshihiro Hayashi, Naoki Furukawa, Yujirou Bunno, Marino Yamamoto, Ryohei Miyazaki, Mitsuko Iguchi, Makoto Toi, Ichiro Murakami, Masaya Tamura

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Article in Medical molecular morphology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Hironobu OkadaDepartment of Thoracic Surgery, Kochi Medical School, Nankoku, Kochi, Japan. jm-hironobu@kochi-u.ac.jp.ORCID http://orcid.org/0000-0001-9355-7972
Yoshihiro HayashiScience Research Center, Kochi-University, Nankoku, Kochi, Japan.
Naoki FurukawaDepartment of Thoracic Surgery, Kochi Medical School, Nankoku, Kochi, Japan.
Yujirou BunnoDepartment of Thoracic Surgery, Kochi Medical School, Nankoku, Kochi, Japan.
Marino YamamotoDepartment of Thoracic Surgery, Kochi Medical School, Nankoku, Kochi, Japan.
Ryohei MiyazakiDepartment of Thoracic Surgery, Kochi Medical School, Nankoku, Kochi, Japan.
Mitsuko IguchiDepartment of Diagnostic Pathology, Kochi Medical School Hospital, Nankoku, Kochi, Japan.
Makoto ToiDepartment of Diagnostic Pathology, Kochi Medical School Hospital, Nankoku, Kochi, Japan.
Ichiro MurakamiDepartment of Pathology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Masaya TamuraDepartment of Thoracic Surgery, Kochi Medical School, Nankoku, Kochi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fascin-1, an actin-bundling protein, plays a crucial role in cancer cell motility, invasion, and epithelial-mesenchymal transition (EMT). While its significance has been demonstrated in several malignancies, its clinical relevance in thymic carcinoma remains unclear. We retrospectively analyzed 10 surgically resected thymic carcinoma cases treated at Kochi University Hospital from 2008 to 2024. Immunohistochemical staining was performed to evaluate Fascin-1 expression using the Allred scoring system. Expression of EMT-related markers (TGF-β, pSmad3, Snail, and E-cadherin) was also assessed. Associations between Fascin-1 expression and postoperative recurrence were analyzed. Fascin-1 was highly expressed in tumor regions with low E-cadherin expression and co-localized with EMT-inducing markers such as TGF-β and Snail. Patients with postoperative recurrence showed significantly higher Fascin-1 scores than those without recurrence (P = 0.048). Double immunofluorescence confirmed an inverse relationship between Fascin-1 and E-cadherin expression. High Fascin-1 expression may serve as a potential marker for postoperative recurrence in thymic carcinoma and is closely associated with EMT. These findings suggest Fascin-1 as a promising prognostic biomarker and therapeutic target, although further studies with larger cohorts and functional analyses are warranted.

Indexed as

Carrier ProteinsEpithelial-Mesenchymal TransitionMicrofilament ProteinsNeoplasm Recurrence, LocalThymomaThymus NeoplasmsAdultAgedBiomarkers, TumorCadherinsFemaleHumansMaleMiddle AgedRetrospective StudiesBiomarkers, TumorCadherinsCarrier ProteinsFSCN1 protein, humanMicrofilament ProteinsEMTFascin-1ImmunohistochemistryThymic cancerThymic carcinoma

Identifiers

PMID40888887

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