Evidence map›Paper›PMID 40888869›Full record

SynthesisInternational forum of allergy & rhinology2025

Prevalence of Venous Sinus Stenosis in Spontaneous Cerebrospinal Fluid Leak and the Role for Venous Sinus Stenting: A Systematic Review and Meta-Analysis.

Jenny B Xiao, Carlos Khalil, Helen Hsiao, Janiss Skulsampaopol, Daniel J Lee, Michael D Cusimano, John M Lee

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International forum of allergy & rhinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jenny B XiaoFaculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0009-0006-9699-3108
Carlos KhalilDivision of Rhinology, Department of Otolaryngology - Head & Neck Surgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-0524-6902
Helen HsiaoFaculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Janiss SkulsampaopolDivision of Neurosurgery, Department of Surgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Daniel J LeeDivision of Rhinology, Department of Otolaryngology - Head & Neck Surgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Michael D CusimanoDivision of Neurosurgery, Department of Surgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
John M LeeDivision of Rhinology, Department of Otolaryngology - Head & Neck Surgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-8473-4674

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGiven the association between spontaneous cerebrospinal fluid (sCSF) leak and idiopathic intracranial hypertension (IIH), and the association of IIH and venous sinus stenosis (VSS), we sought to determine the prevalence of VSS in sCSF leak and the role of venous sinus stenting for sCSF leak.

methodsA protocol was registered in PROSPERO [CRD42024568270]. A search was conducted in four electronic databases: Medline (Ovid), Embase, CINAHL, Web of Science, and Cochrane CENTRAL. Two reviewers independently screened citations and extracted data. Methodological quality was assessed using the Joanna Briggs Institute's critical appraisal tool. Data were pooled using a random effects model to calculate overall prevalence and relative risk (RR).

resultsFifteen studies met the final inclusion criteria, with a total of 372 patients presenting with sCSF leak. The pooled prevalence of VSS in patients with sCSF leak was 0.71 (95% CI: 0.56-0.83, I

conclusionVSS is common in patients with sCSF leak, and adjunctive venous sinus stenting after surgical leak repair may benefit a subset of patients. Further studies are needed to clarify the role of venous sinus stenting in conjunction with surgical repair of leaks.

Indexed as

Cerebrospinal Fluid LeakCranial SinusesPseudotumor CerebriStentsConstriction, PathologicHumansPrevalenceidiopathic intracranial hypertensionspontaneous CSF leakvenous sinus stenosisvenous sinus stent

Identifiers

PMID40888869
PMCPMC12503073

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.