Evidence map›Paper›PMID 40888850›Full record

ArticleNucleic acids research2026

metagRoot: a comprehensive database of protein families associated with plant root microbiomes.

Maria N Chasapi, Iro N Chasapi, Eleni Aplakidou, Fotis A Baltoumas, Evangelos Karatzas, Ioannis Iliopoulos, Dimitrios J Stravopodis, Ioannis Z Emiris, Aydin Buluç, Ilias Georgakopoulos-Soares and 2 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maria N ChasapiInstitute for Fundamental Biomedical Resea rch, BSRC "Alexander Fleming," 16672 Vari, Greece.
Iro N ChasapiInstitute for Fundamental Biomedical Resea rch, BSRC "Alexander Fleming," 16672 Vari, Greece.
Eleni AplakidouInstitute for Fundamental Biomedical Resea rch, BSRC "Alexander Fleming," 16672 Vari, Greece.
Fotis A BaltoumasInstitute for Fundamental Biomedical Resea rch, BSRC "Alexander Fleming," 16672 Vari, Greece.ORCID 0000-0002-2870-2931
Evangelos KaratzasEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, United Kingdom.ORCID 0000-0001-9132-8981
Ioannis IliopoulosDivision of Basic Sciences, University of Crete Medical School, 71110 Heraklion, Greece.ORCID 0000-0002-9079-0565
Dimitrios J StravopodisSection of Cell Biology and Biophysics, Department of Biology, School of Science, National and Kapodistrian University of Athens (NKUA), 15701 Athens, Greece.
Ioannis Z EmirisDepartment of Informatics and Telecommunications, National and Kapodistrian University of Athens, 16122 Athens, Greece.
Aydin BuluçComputational Research Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.
Ilias Georgakopoulos-SoaresInstitute for Personalized Medicine, Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, PA 17033, United States.
Nikos C KyrpidesDOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.
Georgios A PavlopoulosInstitute for Fundamental Biomedical Resea rch, BSRC "Alexander Fleming," 16672 Vari, Greece.ORCID 0000-0002-4577-8276

Funding

European Union's Horizon 2020Hellenic Foundation for Research and Innovation 16718-PRPFORHellenic Foundation for Research and Innovation 23592Hellenic Foundation for Research and Innovation TAEDR-0539180Huck Innovative and Transformational SeedHuck Institutes of the Life SciencesMarie Skłodowska-Curie 945405Nikos Kyrpides JGI-LBNLPenn State College of MedicineU.S. Department of Energy Office of Science DE-AC02-05CH11231
6 · The paper itself

Abstract

The plant root microbiome is vital in plant health, nutrient uptake, and environmental resilience. To explore and harness this diversity, we present metagRoot, a specialized and enriched database focused on the protein families of the plant root microbiome. MetagRoot integrates metagenomic, metatranscriptomic, and reference genome-derived protein data to characterize 71 091 enriched protein families, each containing at least 100 sequences. These families are annotated with multiple sequence alignments, CRISPR elements, hidden Markov models, taxonomic and functional classifications, ecosystem and geolocation metadata, and predicted 3D structures using AlphaFold2. MetagRoot is a powerful tool for decoding the molecular landscape of root-associated microbial communities and advancing microbiome-informed agricultural practices by enriching protein family information with ecological and structural context. The database is available at https://pavlopoulos-lab.org/metagroot/ or https://www.metagroot.org.

Indexed as

Databases, ProteinMicrobiotaPlant RootsMetagenomeMetagenomicsMolecular Sequence Annotation

Identifiers

PMID40888850
PMCPMC12808537

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.