Evidence map›Paper›PMID 40888848›Full record

ReviewCurrent microbiology2025

Bacterial Extracellular Vesicles: Emerging Regulators in the Gut-Organ Axis and Prospective Biomedical Applications.

Bingqi Zhang, Mingyan Liu, Lingxin Jiang, Ziqiu Chen, Wei Tian, Kaidi Li, Bin Yu, Wenlan Zhang, Sirui Li, Yuzhu Zhou and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bingqi Zhang *School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Mingyan Liu *School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Lingxin JiangSchool of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Ziqiu ChenSchool of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Wei TianSchool of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Kaidi LiSchool of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Bin YuSchool of Medical Technology, Tanjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Wenlan ZhangSchool of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Sirui LiSchool of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Yuzhu ZhouSchool of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Huhu LiSchool of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. woshihuhu163@163.com.
Yilan XuJournal Editorial Department, Tanjin University of Traditional Chinese Medicine, Tianjin, 301617, China. xuyilanbjb@163.com.
Yongna DaiSchool of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. daiyongna@foxmail.com.

Funding

National Natural Science Foundation of China No. 81904146National Natural Science Foundation of China No. 82004330Research project on the integrative medicine by the Tianjin Health Commission No. 2023075Tianjin Education Commission Research Project No. 2023ZD024
6 · The paper itself

Abstract

The critical role of gut microbiota and their metabolites in host health has been extensively studied. In recent years, bacterial extracellular vesicles (BEVs) released by gut bacteria have gained increasing attention as carriers of bioactive substances and signaling molecules. This review systematically summarizes the biogenesis of BEVs and their potential regulatory roles in gut-organ axis diseases, including disorders of the central nervous system, kidneys, liver, bones, lungs, cardiovascular system, and metabolism. Additionally, we explore the prospects and applications of BEVs in disease diagnosis and prevention. This paper provides a novel perspective on the multifaceted roles of BEVs in host health and disease and lays a theoretical foundation for the development of BEV-based diagnostic and therapeutic tools in future.

Indexed as

BacteriaExtracellular VesiclesGastrointestinal MicrobiomeAnimalsHumans

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.