Evidence map›Paper›PMID 40888825›Full record

ReviewCell biochemistry and biophysics2025

Innovative Nanotechnology and Molecular Probes for Real-time Monitoring and Therapeutic Modulation of Pyroptosis in Cancer and Inflammatory Diseases.

Wajahat Ali, Zainab Saba, Muhammad Saqib, Shabana Batool, Awais, Fatima Rahman, Ali Asgher Shuja, Junaid Abid, Seema Batool, Kulsoom and 4 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Wajahat Ali *School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, 710061, China. aliwajahat@stu.xjtu.edu.cn.
Zainab Saba *Institute of Health Sciences, Department of Optometry, Khwaja Fareed University of Engineering and Technology, Rahim Yar Khan, Pakistan.
Muhammad SaqibKey Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an jiaotong University, Xi'an, 710049, China.
Shabana BatoolKey Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an jiaotong University, Xi'an, 710049, China.
AwaisDepartment of Computer Science, Government Graduate College, Muzaffargarh, Pakistan.
Fatima RahmanDepartment of Biochemistry and Biotechnology, The Women University, Multan, Pakistan.
Ali Asgher ShujaDepartment of Basic Medical Sciences, Faculty of Pharmacy, Salim Habib University, Karachi, Pakistan.
Junaid AbidDepartment of Food Science and Technology, University of Haripur, Haripur, Pakistan.
Seema BatoolDepartment of Development and Environmental Studies, Arctic Studies, University of Paris Saclay, Saclay, France.
Kulsoom *School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, 710061, China. Kulsoomsana@stu.xjtu.edu.cn.
Mukhayya RuzievaDepartment of General Science, Mamun University, Khiva, Uzbekistan.ORCID http://orcid.org/0009-0006-8541-1037
Murodjon YaxshimuratovDepartment of Chemistry, Urgench State University, Urgench, Uzbekistan.ORCID http://orcid.org/0009-0008-9500-1239
Ravshan SultanovDepartment of Medical Fundamental Sciences, Termez University of Economics and Service, Termez, Uzbekistan.ORCID http://orcid.org/0009-0003-6820-1044
Yuldoshev Jushkinbek Erkaboy UgliDepartment of Pedagogy and Primary Education Methodology (Intern Teacher), Urgench Innovation University, Urgench, Uzbekistan.ORCID http://orcid.org/0000-0002-4464-6423

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyroptosis is a recently identified form of programmed cell death that plays a crucial role in tumor development and immune regulation. It provides various novel perspectives on prognostic markers and possible therapeutic approaches. Unlike necrosis and apoptosis, pyroptosis, is characterized by the activation of pore-forming protein called gasdermin D (GSDMD), which is cleaved by caspase enzymes to form oligomers that disrupt the cell membrane, leading to rapid cell lysis. The interaction between pyroptosis and immunotherapy presents promising opportunities to enhance cancer treatments and improve patient outcomes. However, despite extensive research, the underlying mechanisms of pyroptosis are not yet fully understood. Recent advancements have focused on noninvasive and real-time imaging techniques to elucidate pyroptosis dynamics at the molecular level. This review comprehensively discusses innovative monitoring strategies, including molecular probes, nanotechnology-based tools, and computational approaches, which provide valuable insights into pyroptosis regulation. By leveraging these advanced methodologies, researchers can refine therapeutic strategies, paving the way for more effective and personalized treatments for cancer and inflammatory diseases.

Indexed as

InflammationMolecular ProbesNanotechnologyNeoplasmsPyroptosisAnimalsGasderminsHumansImmunotherapyGasderminsMolecular ProbesCancer cellsCaspaseGasdermin (GSDM)ImmunotherapyInflammasomeInflammatory diseasesNanoprobesNoninvasive monitoringPyroptosis

Identifiers

PMID40888825

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.