Evidence map›Paper›PMID 40888762›Full record

ArticleThe Journal of cell biology2025

Allocation of resources among multiple daughter cells.

Alison C E Wirshing, Roberto Alonso-Matilla, Michelle Yan, Samra Khalid, Analeigha V Colarusso, David Odde, Daniel J Lew

Abstract read
In one paragraph

Article in The Journal of cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Organelle scaling over a 100-fold cell size range.bioRxiv : the preprint server for biology · 2026
    Article
  3. Organelle partitioning in the multi-budding yeastbioRxiv : the preprint server for biology · 2026
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Alison C E WirshingDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-2362-0531
Roberto Alonso-MatillaDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-8296-6831
Michelle YanDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0009-0003-6693-0964
Samra KhalidDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0009-0000-9951-1019
Analeigha V ColarussoDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0009-0004-2644-4790
David OddeDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-7731-2799
Daniel J LewDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-7482-3585

Funding

Project 3P01CA254849 · NCI · UNIVERSITY OF MINNESOTA · PI LARGAESPADA, DAVID ANDREW, MASOPUST, DAVID · 2021 to 2025
$9.4M
TECH CoreU54CA268069 · NCI · UNIVERSITY OF MINNESOTA · PI David J. Odde · 2022 to 2026
$8.2M
Studies on cell polarity, chemotropism, and cell cycle controlR35GM122488 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI DANIEL J LEW · 2017 to 2026
$6.9M
NCI NIH HHS P01CA254849NCI NIH HHS U54CA268069NIGMS NIH HHS R35 GM122488NIGMS NIH HHS R35GM122488
6 · The paper itself

Abstract

Cell division commonly produces two daughter cells, but there are many exceptions where large cells produce multiple daughters. Multiple fission of some green algae and bacteria; cellularization during embryogenesis of plants and insects; and growth of Ichthyosporeans, Chytrids, and Apicomplexans all provide variations on this theme. In some yeast species, a large multinucleate mother cell grows multiple buds (daughters) simultaneously. Here, we address how mothers partition growth equally among their buds in the multi-budding yeast Aureobasidium pullulans. Bud growth is directed by actin cable networks that appear to be optimized for even partitioning despite complex cell geometries. Even partitioning does not rely on compensatory mechanisms to adjust bud volumes but rather stems directly from effective equalization of polarity sites. These results reveal how conserved cell polarity and cytoskeletal networks are adapted to build complex morphologies in fungi.

Indexed as

AscomycotaCell DivisionActin CytoskeletonActinsCell PolarityFungal ProteinsActinsFungal Proteins

Identifiers

PMID40888762
PMCPMC13207765

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.