Evidence map›Paper›PMID 40888668›Full record

ReviewJournal of magnetic resonance imaging : JMRI2026

Technologies and Strategies for Metabolic and Molecular Imaging With Hyperpolarized MRI.

Alixander S Khan, Christoffer Laustsen

Abstract readReview
In one paragraph

Review in Journal of magnetic resonance imaging : JMRI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Hyperpolarized MRI theranostics in cancer.Frontiers in oncology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alixander S KhanMR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Christoffer LaustsenMR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-0317-2911

Funding

Karen Elise Jensens FondKræftens BekæmpelseLundbeck FoundationNovo Nordisk Fonden
6 · The paper itself

Abstract

Conventional Magnetic Resonance Imaging (MRI) offers limited sensitivity for direct metabolic and molecular imaging using non-proton nuclei due to low thermal nuclear spin polarization. Hyperpolarization (HP) technologies increase nuclear spin polarization by several orders of magnitude, overcoming this limitation to enable in vivo studies of biochemistry and physiology. A growing body of literature has shown the value in HP technologies offering metabolic and functional information useful for a variety of clinical applications. This review details the complete workflow of hyperpolarized MRI, from the methodologies used to produce hyperpolarized samples and the range of available probes to the specific imaging acquisition and data analysis strategies required to maximize the signal, and finally, its major clinical applications. EVIDENCE LEVEL: 5. TECHNICAL EFFICACY: Stage 3.

Indexed as

Magnetic Resonance ImagingMolecular ImagingAnimalsHumansd‐DNPhyperpolarizationPHIPSEOP

Identifiers

PMID40888668
PMCPMC12810999

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.