Observational studyScience progress
Associations between NETosis-related genes and 28-day mortality in patients with sepsis: An observational retrospective study and bioinformatic analysis.
Observational study in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Neutrophil extracellular traps associated with severity and prognosis of community-acquired pneumonia.Clinical and experimental medicine · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ObjectiveSepsis, a systemic inflammatory response triggered by infection, is characterized by organ dysfunction. NETosis, a form of cell death involving the release of neutrophil extracellular traps (NETs), plays a crucial antimicrobial role during sepsis. This study aimed to explore the relationship between NETosis-related genes (NRGs) and 28-day mortality in patients with sepsis.MethodsThis retrospective observational study utilized the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Univariate and multivariate logistic regression analyses were conducted to identify independent prognostic factors. A nomogram was then constructed to assess the potential of these factors in predicting 28-day mortality in patients with sepsis. Additionally, a Mendelian randomization (MR) study was performed to identify NRGs with causal associations to 28-day mortality in sepsis. Expression validation was carried out using the GSE65682 dataset from a public database, followed by identification of key genes. Enrichment analysis was performed to uncover the molecular mechanisms associated with these key genes in sepsis.ResultsA total of 909 patients with sepsis (706 survivors and 203 non-survivors) were identified from the MIMIC-IV database. Seven independent prognostic factors, including absolute neutrophil counts, were identified. The nomogram developed proved to be a reliable tool for predicting 28-day mortality in patients with sepsis. The MR study identified 12 NRGs with a unidirectional causal relationship to 28-day mortality, with AKT1 and CXCR2 emerging as key genes. Both genes are predominantly involved in immune-related pathways.ConclusionAnalysis of the MIMIC-IV database highlighted neutrophil_abs as a significant prognostic factor for 28-day mortality in sepsis. Transcriptomic analysis identified AKT1 and CXCR2 as critical genes associated with 28-day mortality, providing insights into potential therapeutic strategies for sepsis.
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