Evidence map›Paper›PMID 40888567›Full record

ArticleThe Journal of organic chemistry2025

To PLP or Not to PLP: Stereodivergent Transaminase-Catalyzed Reactions Directed by Kinetic and Thermodynamic Control.

Madeline J Fitzgerald, Xiaoyan Li, Dawei Peng, Chenlu Qin, Yuehan Sun, Chloe C Wang, YeePui Yeung, Chi Nguyen, Hanna M Key

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of organic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Madeline J FitzgeraldDepartment of Chemistry, University of California, Berkeley, California 94720-1460, United States.ORCID 0000-0003-1299-0155
Xiaoyan LiDepartment of Chemistry, University of Michigan, 930 N University Ave, Ann Arbor, Michigan 48109, United States.
Dawei PengDepartment of Biostatistics, Yale School of Public Health, 60 College Street, New Haven, Connecticut 06520-0834, United States.
Chenlu QinDepartment of Radiation Oncology Duke University Medical Center. Duke Cancer Center, Medicine Circle, Durham, North Carolina 27710, United States.
Yuehan SunDepartment of Chemistry, Davidson College, Davidson, North Carolina 28036, United States.
Chloe C WangDepartment of Chemistry, Davidson College, Davidson, North Carolina 28036, United States.
YeePui YeungCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, United States.
Chi NguyenDepartment of Chemistry, Davidson College, Davidson, North Carolina 28036, United States.
Hanna M KeyDepartment of Chemistry, Davidson College, Davidson, North Carolina 28036, United States.ORCID 0009-0008-3630-300X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selective catalysis is a key objective in organic synthesis, and reactions with differing kinetic and thermodynamic products present the opportunity for divergent reaction outcomes with a single catalyst. We report a biocatalytic method in which a single transaminase can form either

Indexed as

CyclohexanonesCyclohexylaminesPyridoxal PhosphateTransaminasesBiocatalysisCatalysisEscherichia coliKineticsMolecular StructureStereoisomerismThermodynamicsCyclohexanonesCyclohexylaminesPyridoxal PhosphateTransaminases

Identifiers

PMID40888567
PMCPMC12442079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.