ArticleThe Laryngoscope2026
Laryngeal Basal Cell Response to Cigarette Smoke and E-Cigarette Aerosol Exposures.
Article in The Laryngoscope, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectiveThe laryngeal epithelium contains a basal cell (BC) layer. The BC layer is a reservoir of progenitor cells necessary for the formation and regeneration of the epithelium. The epithelium is susceptible to the deposition of inhaled irritants such as cigarette smoke (CS) and electronic cigarette (E-Cig) aerosol. The objective of this study was to quantify BC, proliferating cells, and epithelial histologic architecture in the larynx following a 6-week exposure to CS or E-Cig aerosol.
methodsMice (N = 12) were assigned to a room-air control, CS-exposed, or an E-Cig-exposed group. Exposures were conducted for 2 h per day, 5 days a week for a total of 6 weeks. Mice were then euthanized and the larynx was evaluated using immunofluorescence and histology. We assessed p63-positive BCs, Ki67-positive proliferating cells, p63 and Ki67 colocalized cells, overall cellularity, and epithelial thickness across the supraglottic, vocal fold, and subglottic regions of the larynx.
resultsFollowing E-Cig exposure, there was a significant reduction in p63-positive BC in the vocal folds as compared to the CS-exposed and control group and epithelial thickness compared to the CS-exposed group. No significant changes were observed in the numbers of BCs, proliferating cells, colocalized cells, or overall cellularity in any of the other laryngeal regions examined.
conclusionAn E-Cig-induced reduction in BCs within the vocal fold epithelium may have implications for decreased regenerative capacity. Overall, our findings highlight distinct epithelial responses to CS and E-Cig exposures and underscore the regional heterogeneity of the laryngeal response to these common inhaled challenges.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.