ArticleEuropean journal of neurology2025
Does the Timing of Electroencephalogram Recording After a First Unprovoked Seizure Influence Its Ability to Predict Additional Seizures?
Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Does the Timing of Electroencephalogram Recording After a First Unprovoked Seizure Influence Its Ability to Predict Additional Seizures?European journal of neurology · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAbnormal electroencephalograms (EEGs) are a known risk factor for additional seizures following a first unprovoked seizure (FUS). This study assessed whether early or late EEGs after a FUS predict subsequent seizures in pediatric and adult patients.
methodsThis retrospective study included patients who underwent EEGs after a FUS between 4/2011 and 12/2015, categorized into children (≤ 16 years) and adults. EEGs (assigned as generally abnormal or specifically epileptiform) performed early (within 2 days) or later were correlated with patient characteristics, anti-seizure medication (ASM) use, and additional seizures within 2 years.
resultsThe study involved 202 participants (137 children, 65 adults) with 168 early and 127 late EEGs. Children had more abnormal early and late EEGs than adults, though early EEGs were conducted sooner in adults. More early EEGs in children showed epileptiform activity. ASMs were more frequently prescribed in adults, patients with risk factors, and those with abnormal early EEGs, but ASM use did not correlate with less abnormal late EEGs. Epileptiform activity in late EEGs (p = 0.006, OR 3.085) and ASM use (p = 0.018, OR 0.39) were significantly linked to additional seizures on multivariate analysis, with similar findings in pediatric but not adult patients.
conclusionsBoth early and late EEGs are valuable following a FUS, serving different purposes. Early EEGs are helpful for diagnosis, while late EEGs offer better prognostic value for seizure recurrence. Further research is needed to confirm these results in larger, prospective studies.
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