Evidence map›Paper›PMID 40888414›Full record

ArticleJournal of cosmetic dermatology2025

Evaluating the Efficacy and Safety of Deoxycholic Acid Injection in Reduction of Flank Fat.

Navid Namakizadeh Esfahani, Faezeh Khorasanizadeh, Amirhoushang Ehsani, Maryam Nasimi, Hamidreza Mahmoudi, Hamidreza Kafi, Araz Sabzvari, Hoshyar Gholami, Keysan Saeedi, Kamran Balighi

Abstract read
In one paragraph

Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Navid Namakizadeh EsfahaniDepartment of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-1746-6283
Faezeh KhorasanizadehAdvanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, Iran.
Amirhoushang EhsaniDepartment of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Maryam NasimiDepartment of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-0571-5940
Hamidreza MahmoudiDepartment of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-1890-1005
Hamidreza KafiMedical Department, Orchid Pharmed Company, Tehran, Iran.
Araz SabzvariCinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Hoshyar GholamiEspad Pharmed Darou Company, Tehran, Iran.
Keysan SaeediDepartment of Industrial Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran.
Kamran BalighiDepartment of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-8059-670X

Funding

Espad Pharmed Darou Company
6 · The paper itself

Abstract

backgroundDeoxycholic acid (DCA) injection is a noninvasive method for localized fat reduction, offering lower risks compared to invasive techniques. This study evaluates the safety and efficacy of DCA injections for reducing flank fat.

aimsWe assessed the efficacy and safety of DCA injections for flank fat reduction over a 12-week period using imaging, anthropometric data, Global Aesthetic Improvement Scale (GAIS) scoring, participant satisfaction, and standardized adverse event reporting. PATIENTS/

methodsAdults aged 21-65 years with mild to moderate flank fat (≥ 2 cm) received two sessions of 10 mg/mL DCA injections, 6 weeks apart. Standardized ultrasound and caliper measurements were performed prior to each session. Injections were administered at 0.1-0.15 mL per 1 × 1 cm

resultsThirty participants (mean age 34.9 years; 86.7% female) completed the study. By Week 12, 86.7% showed aesthetic improvement based on GAIS score, with significant reductions in waist circumference and fat thickness (measured using caliper and ultrasound; p < 0.001). The procedure was generally safe, with most adverse events being mild to moderate and limited to the injection site.

conclusionDCA injections effectively reduced localized flank fat after two treatment sessions, resulting in significant aesthetic improvements. Adverse events were mostly mild and manageable, with no serious complications.

Indexed as

Cosmetic TechniquesDeoxycholic AcidSubcutaneous FatAdultAgedEstheticsFemaleHumansInjections, SubcutaneousMaleMiddle AgedPatient SatisfactionTreatment OutcomeUltrasonographyWaist CircumferenceYoung AdultDeoxycholic Acidfat injectionslipolysisnoninvasive

Identifiers

PMID40888414
PMCPMC12400788

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.