Evidence map›Paper›PMID 40888302›Full record

ArticleJournal of diabetes2025

Associations of Stressful Life Events With Diabetes Incidence in China: Insights From the China Kadoorie Biobank.

Jing Qian, Huiying Cheng, Xuening Dai, Dianjianyi Sun, Pei Pei, Meng Wang, Yingjun Li

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jing QianDepartment of Epidemiology and Health Statistics, School of Public Health, Hangzhou Medical College, Hangzhou, China.
Huiying ChengDepartment of Epidemiology and Health Statistics, School of Public Health, Hangzhou Medical College, Hangzhou, China.
Xuening DaiDepartment of Epidemiology and Health Statistics, School of Public Health, Hangzhou Medical College, Hangzhou, China.
Dianjianyi SunDepartment of Epidemiology & Biostatistics, School of Public Health, Peking University, Haidian District Beijing, China.
Pei PeiPeking University, Center for Public Health and Epidemic Preparedness and Response, Beijing, China.
Meng WangZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
Yingjun LiDepartment of Epidemiology and Health Statistics, School of Public Health, Hangzhou Medical College, Hangzhou, China.ORCID https://orcid.org/0000-0001-8899-916X

Funding

Noncommunicable Chronic Diseases-National Science and Technology Major Project 2023ZD0510100Noncommunicable Chronic Diseases-National Science and Technology Major Project 2023ZD0510104Zhejiang Province Key Science and Technology Plan for Medicine and Health WKJ-ZJ-2333
6 · The paper itself

Abstract

backgroundLimited empirical evidence exists on the link between exposure to various stressful life events (SLEs) and the heightened risk of Diabetes Mellitus (DM) within the mainland Chinese population.

methodsWe conducted this prospective cohort study with 455,464 participants from the China Kadoorie Biobank (CKB); we examined associations between SLEs exposures and DM outcomes. We employed multivariable Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for potential confounders.

resultsOver a median follow-up of 10.1 years, 14,218 DM cases were identified. A dose-response relationship was observed between the number of SLEs, personal-related events, and the risk of DM. The higher the number of SLEs experienced, the higher the risk of developing diabetes (HR = 1.06, 95% CI = 1.01-1.12); individuals who experienced personal-related events had a higher risk of developing DM (HR = 1.17, 95% CI = 1.01-1.36), and those who experienced marital separation/divorce had a 53% increased risk of DM (HR = 1.53, 95% CI = 1.12-2.09). Subgroup analyses revealed effect modifications based on birth cohort, sex, and area.

conclusionBy exploring the association of multiple SLEs with the development of DM, we identified marital separation/divorce as a driver of increased DM risk.

Indexed as

Diabetes MellitusLife Change EventsStress, PsychologicalAdultAgedBiological Specimen BanksChinaFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedProportional Hazards ModelsProspective StudiesRisk FactorsChina Kadoorie Biobankdiabetes mellitusprevention strategiespublic healthstressful life events

Identifiers

PMID40888302
PMCPMC12400066

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.