ArticleAdvanced healthcare materials2025
Co-Delivery of Ca-MOF and Mg-MOF Using Nanoengineered Hydrogels to Promote In Situ Mineralization and Bone Defect Repair: In Vitro and In Vivo Analysis.
Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Metal-Organic Framework Nanozymes: From Rational Design and Synthesis to Biomedical Applications.Nano-micro letters · 2026Review
- Converging chemistry and clinical orthopedics in the emerging role of MOFs in advanced bone defect repair.Theranostics · 2026Review
- Co-Delivery of Ca-MOF and Mg-MOF Using Nanoengineered Hydrogels to Promote In Situ Mineralization and Bone Defect Repair: In Vitro and In Vivo Analysis.Advanced healthcare materials · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Severe bone defects resulting from traumatic injuries or infections are severe skeletal deficiencies that are unable to regenerate on their own. Despite their effectiveness, current treatments including allografts and artificial bone substitutes, have several drawbacks. This includes poor osseointegration, low biocompatibility and biodegradability, limited cell infiltration, and adverse side effects arising from drug-loaded substitutes. To overcome these challenges, mineral-based metal-organic frameworks (MOFs) nanoparticles are successfully synthesized and incorporated into polymeric hydrogels to promote bone healing. The study demonstrates that the combination of Ca-MOF and Mg-MOF (Ca/Mg-MOF) nanoparticles, when incorporated into a hydrogel scaffold, can take various forms: sprayable, injectable, and coating material for orthopedic implants. Furthermore, nanoengineered hydrogels significantly enhance osteogenic differentiation and mineral deposition of preosteoblast cells compared to control groups and individual MOFs. This osteogenic property can be attributed to the cumulative release of Ca
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Registered trials
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