ArticleMuscle & nerve2025
The Effect of Anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Human Autoantibodies on Muscle Regeneration in Mice.
Article in Muscle & nerve, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
7 authors.
Funding
Abstract
INTRODUCTION/
aimsAnti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) autoantibodies (aAbs) are pathogenic in immune-mediated necrotizing myopathy (IMNM), partly through complement activation. C5 inhibition did not restore muscle strength in mice or patients with overt IMNM, suggesting additional pathogenic mechanisms. In vitro studies have suggested that anti-HMGCR aAbs might impair myoblast fusion and myotube differentiation, but this has not been investigated in vivo. This study aimed at assessing the impact of anti-HMGCR aAbs on muscle regeneration in a mouse model of muscle necrosis.
methodsMuscle necrosis was induced by cardiotoxin (CTX) injection into the gastrocnemius of C57BL/6 or C5-deficient C57BL/10 mice. Mice received intraperitoneal injections of IgG purified from an anti-HMGCR
resultsIn C5-deficient mice, anti-HMGCR
conclusionThese findings establish the cytotoxicity of anti-HMGCR aAbs on regenerating muscle cells through a primarily complement-mediated mechanism, without directly impairing cellular regeneration per se. Given the still unmet medical needs of IMNM, C5 or upstream complement-targeted therapies early in the disease course, as well as aAb reduction, B/plasma cell depletion via CAR-T cells or bispecific antibodies deserves further clinical investigation.
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