Evidence map›Paper›PMID 40888076›Full record

ArticleHistology and histopathology2026

Morphological changes in microglia in the mouse brain during postnatal development and obesity.

Yang Li, Chu Zhang, Ge Gao, Xiaonan Shao, Jing Kang, Xin Yan, Juntang Lin, Liang Qiao

Abstract read
PubMed Publisher
In one paragraph

Article in Histology and histopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yang Li *Stem Cells and Biotherapy Engineering Research Center of Henan, National Joint Engineering Laboratory of Stem Cells and Biotherapy, School of Life Sciences and Technology, Xinxiang Medical University, Xinxiang, China.
Chu Zhang *Stem Cells and Biotherapy Engineering Research Center of Henan, National Joint Engineering Laboratory of Stem Cells and Biotherapy, School of Life Sciences and Technology, Xinxiang Medical University, Xinxiang, China.
Ge Gao *Stem Cells and Biotherapy Engineering Research Center of Henan, National Joint Engineering Laboratory of Stem Cells and Biotherapy, School of Life Sciences and Technology, Xinxiang Medical University, Xinxiang, China.
Xiaonan ShaoStem Cells and Biotherapy Engineering Research Center of Henan, National Joint Engineering Laboratory of Stem Cells and Biotherapy, School of Life Sciences and Technology, Xinxiang Medical University, Xinxiang, China.
Jing KangStem Cells and Biotherapy Engineering Research Center of Henan, National Joint Engineering Laboratory of Stem Cells and Biotherapy, School of Life Sciences and Technology, Xinxiang Medical University, Xinxiang, China.
Xin YanTranslational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, Rostock, Germany.
Juntang LinStem Cells and Biotherapy Engineering Research Center of Henan, National Joint Engineering Laboratory of Stem Cells and Biotherapy, School of Life Sciences and Technology, Xinxiang Medical University, Xinxiang, China. linjt@xxmu.edu.cn.
Liang QiaoStem Cells and Biotherapy Engineering Research Center of Henan, National Joint Engineering Laboratory of Stem Cells and Biotherapy, School of Life Sciences and Technology, Xinxiang Medical University, Xinxiang, China. liang.qiao@xxmu.edu.cn.

Funding

College Students' Innovation and Entrepreneurship Training Program 202410472006Deutsche Forschungsgemeinschaft YA 721/3-1Foundation for Doctoral Scientific Research Program of Xinxiang Medical University 505511Foundation for Doctoral Scientific Research Program of Xinxiang Medical University XYBSKYZZ202124Foundation for Doctoral Scientific Research Program of Xinxiang Medical University XYKJXX202501Foundation for Doctoral Scientific Research Program of Xinxiang Medical University XYKJXX506017Key Technologies R and D Program of Henan Province 232102310288National Natural Science Foundation of China 82071326Natural Science Foundation of Henan 252300421395Research Innovation Support Program for Postgraduates of Xinxiang Medical University YJSCX202335Y
6 · The paper itself

Abstract

Microglia are innate immune cells in the central nervous system (CNS) and play critical roles in proper brain development and function. During postnatal development, microglia have a highly plastic morphology and change rapidly in response to the temporal brain environment. However, their dynamics and phenotypes during this period are still not fully elucidated. Here, we systematically elucidated microglial density and morphological changes during postnatal development as well as in pathological obese conditions. Our results demonstrated a spatiotemporal distribution of microglia in different brain regions associated with gradually increased microglial complexity during postnatal development. Moreover, microglia become reactive in most brain regions of obese mice, but their morphological diversity has a region-specific manner, with an obvious alteration in the hypothalamus. Overall, our data emphasized the morphological dynamics of microglia following developing time windows and provided the basic information for future investigations.

Indexed as

BrainMicrogliaObesityAnimalsAnimals, NewbornMaleMiceMice, Inbred C57BL

Identifiers

PMID40888076

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.