Evidence map›Paper›PMID 40888033›Full record

ArticleZoonoses and public health2025

Highly Pathogenic Avian Influenza A (H5N1) Infection in Bearded Vultures in Spain.

Remigio Martínez, Irene Agulló-Ros, Moisés Gonzálvez, María J Ruano, Bianca Zecchin, Irene Zorrilla, Rafael Guerra, Jorge Paniagua, David Cano-Terriza, Ignacio García-Bocanegra

Abstract read
In one paragraph

Article in Zoonoses and public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Counting cases, conserving species: addressing highly pathogenic avian influenza in wildlife.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Remigio MartínezDepartamento de Sanidad Animal, Grupo de Investigación en Sanidad Animal y Zoonosis (GISAZ), UIC Zoonosis y Enfermedades Emergentes ENZOEM, Universidad de Córdoba, Córdoba, Spain.ORCID https://orcid.org/0000-0002-5908-9447
Irene Agulló-RosDepartamento de Anatomía y Anatomía Patológica Comparadas y Toxicología, Grupo de Investigación en Sanidad Animal y Zoonosis (GISAZ), UIC Zoonosis y Enfermedades Emergentes ENZOEM, Universidad de Córdoba, Córdoba, Spain.
Moisés GonzálvezDepartamento de Sanidad Animal, Grupo de Investigación en Sanidad Animal y Zoonosis (GISAZ), UIC Zoonosis y Enfermedades Emergentes ENZOEM, Universidad de Córdoba, Córdoba, Spain.ORCID https://orcid.org/0000-0003-0423-3189
María J RuanoLaboratorio Central de Veterinaria (LCV), Ministerio de Agricultura, Pesca y Alimentación, Madrid, Spain.
Bianca ZecchinEU Reference Laboratory (EURL) for Avian Influenza and Newcastle Disease, Istituto Zooprofilattico Sperimentale Delle Venezie, Legnaro, Italy.
Irene ZorrillaCentro de Análisis y Diagnóstico de la Fauna Silvestre en Andalucía, Agencia de Medio, Ambiente y Agua M.P., Junta de Andalucía, Málaga, Spain.ORCID https://orcid.org/0000-0003-2169-7348
Rafael GuerraCentro de Conservación Zoo Córdoba, Córdoba, Spain.
Jorge PaniaguaDepartamento de Sanidad Animal, Grupo de Investigación en Sanidad Animal y Zoonosis (GISAZ), UIC Zoonosis y Enfermedades Emergentes ENZOEM, Universidad de Córdoba, Córdoba, Spain.ORCID https://orcid.org/0000-0001-5275-9156
David Cano-TerrizaDepartamento de Sanidad Animal, Grupo de Investigación en Sanidad Animal y Zoonosis (GISAZ), UIC Zoonosis y Enfermedades Emergentes ENZOEM, Universidad de Córdoba, Córdoba, Spain.ORCID https://orcid.org/0000-0001-5657-2567
Ignacio García-BocanegraDepartamento de Sanidad Animal, Grupo de Investigación en Sanidad Animal y Zoonosis (GISAZ), UIC Zoonosis y Enfermedades Emergentes ENZOEM, Universidad de Córdoba, Córdoba, Spain.ORCID https://orcid.org/0000-0003-3388-2604

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report mortality in bearded vultures ( Gypaetus barbatus ) associated with highly pathogenic avian influenza HPAI A H5N1 clade 2.3.4.4b, responsible for the current HPAI panzootic. Between April and May 2022, a total of five bearded vultures from Spain, four free-ranging and one captive individual, were found dead in their nest or with acute symptoms of disease. Complete necropsies were performed and histopathological, immunohistochemistry and molecular analyses were carried out. The presence of the HPAI H5N1 virus was confirmed in different organs, oropharyngeal and cloacal swabs and feathers from the affected individuals. The complete viral genome was obtained from three of the affected bearded vultures. Phylogenetic analyses revealed that the sequences obtained from the free-ranging individuals and the captive specimen belonged to the clade 2.3.4.4b and clustered separately. Furthermore, it supports that direct or indirect contact with other sympatric wild birds could be the most likely source of infection. This research highlights the susceptibility of the endangered bearded vulture to HPAI H5N1, thereby contributing to the broader understanding of the virus's host range.

Indexed as

FalconiformesInfluenza A Virus, H5N1 SubtypeInfluenza in BirdsAnimalsAnimals, WildPhylogenySpainavian fluHPAIimmunopathologyRT‐PCRvulturezoonoses

Identifiers

PMID40888033
PMCPMC12400008

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.