Evidence map›Paper›PMID 40888031›Full record

ArticleJournal of cell science2025

Histone deacetylase 7 mediates lipopolysaccharide-inducible mitochondrial fission in macrophages.

Rishika Abrol, Syeda Farhana Afroz, James E B Curson, Karoline D Raven, Kaustav Das Gupta, Kimberley S Gunther, Alun Jones, Robert C Reid, Zherui Xiong, Jennifer H Gunter and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Rishika AbrolInstitute for Molecular Bioscience , The University of Queensland, Brisbane, QLD 4072, Australia.
Syeda Farhana AfrozInstitute for Molecular Bioscience , The University of Queensland, Brisbane, QLD 4072, Australia.
James E B CursonInstitute for Molecular Bioscience , The University of Queensland, Brisbane, QLD 4072, Australia.
Karoline D RavenInstitute for Molecular Bioscience , The University of Queensland, Brisbane, QLD 4072, Australia.
Kaustav Das GuptaInstitute for Molecular Bioscience , The University of Queensland, Brisbane, QLD 4072, Australia.
Kimberley S GuntherInstitute for Molecular Bioscience , The University of Queensland, Brisbane, QLD 4072, Australia.
Alun JonesInstitute for Molecular Bioscience , The University of Queensland, Brisbane, QLD 4072, Australia.
Robert C ReidInstitute for Molecular Bioscience , The University of Queensland, Brisbane, QLD 4072, Australia.
Zherui XiongInstitute for Molecular Bioscience , The University of Queensland, Brisbane, QLD 4072, Australia.
Jennifer H GunterQueensland University of Technology (QUT), Australian Prostate Cancer Research Centre - Queensland, Centre for Genomics and Personalised Health, School of Biomedical Sciences, Translational Research Institute, Brisbane, QLD 4102, Australia.
Jessica A EngelQIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Christian R EngwerdaQIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Antje BlumenthalFrazer Institute , The University of Queensland, Brisbane, QLD 4102, Australia.
David P FairlieInstitute for Molecular Bioscience , The University of Queensland, Brisbane, QLD 4072, Australia.
Robert G PartonInstitute for Molecular Bioscience , The University of Queensland, Brisbane, QLD 4072, Australia.
Steven ZurynClem Jones Centre for Ageing Dementia Research , Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia.
Ronan KapetanovicInstitute for Molecular Bioscience , The University of Queensland, Brisbane, QLD 4072, Australia.
Divya RamnathInstitute for Molecular Bioscience , The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-1935-9043
Matthew J SweetInstitute for Molecular Bioscience , The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-0406-8139

Funding

Australian Infectious Disease Research CentreAustralian Research Council DP230102124Australian Research Council FT220100487National Health and Medical Research Council 1184885National Health and Medical Research Council 1194406National Health and Medical Research Council 2009551National Health and Medical Research Council 2027755The University of Queensland
6 · The paper itself

Abstract

Histone deacetylase 7 (HDAC7) drives several immunometabolism-related processes in macrophages including lipopolysaccharide (LPS)-inducible glycolysis and inflammatory mediator production. Using an advanced biotin ligase TurboID system in human macrophages, we report 104 candidate HDAC7 interaction partners that might contribute to its immunometabolic functions. One such protein is the mitochondrial fission-promoting GTPase dynamin-related protein 1 (DRP1, also known as DNM1L), which associates with HDAC7 in cells. Using gain- and loss-of-function genetic approaches, we show that HDAC7 promotes LPS-inducible mitochondrial fission in macrophages, as well as DRP1-dependent metabolic and inflammatory responses. HDAC7 enzymatic activity was dispensable for LPS-inducible fission, as previously reported for LPS-inducible glycolysis. However, a pharmacological inhibitor of HDAC7 attenuated fission in primary human and mouse macrophages, implicating its acetyl-lysine docking function in this response. HDAC7 thus drives inducible mitochondrial fission in macrophages. Small molecules targeting the acetyl-lysine docking function of HDAC7 might have applications in preventing pathological processes driven by dysregulated mitochondrial fission.

Indexed as

Histone DeacetylasesLipopolysaccharidesMacrophagesMitochondriaMitochondrial DynamicsAnimalsDynaminsHumansMiceMice, Inbred C57BLMitochondrial ProteinsDNM1L protein, humanDynaminsHDAC7 protein, humanHistone DeacetylasesLipopolysaccharidesMitochondrial ProteinsDynamin-related protein 1GlycolysisHistone deacetylaseImmunometabolismLysine deacetylaseMacrophagesMitochondrial dynamicsMitochondrial fissionPost-translational modificationToll-like receptor

Identifiers

PMID40888031
PMCPMC12539210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.