ArticleThe American journal of sports medicine2025
Relationship Between Early Cartilage Degeneration With T1ρ and T2 Analysis in Medial Tibial Cartilage and 10-Year Posttraumatic Osteoarthritis Progression After ACL Reconstruction.
Article in The American journal of sports medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Evaluation of Pre-Operative Cartilage and Meniscus Ultrashort Echo Time T2* as Biomarkers of Long-Term Clinical Outcomes Following Anterior Cruciate Ligament Reconstruction.Journal of magnetic resonance imaging : JMRI · 2026Article
- Acute and chronic injury of the knee articular cartilage: prevalence, injury mechanisms, MRI assessment and association with osteoarthritis.Skeletal radiology · 2026Review
- Cellular and molecular landscapes of inflammation in anterior cruciate ligament rupture patients are independent on concurrent meniscal injury.Arthritis research & therapy · 2026Article
- Preventing osteoarthritis after anterior cruciate ligament injury: The case for targeting pre-osteoarthritis illness.Osteoarthritis and cartilage · 2026Article
- Correlation Between T1 Rho Value of Magnetic Resonance and Clinical Characteristics of Patients with Knee Osteoarthritis and Analysis of Related Factors of T1 Rho Value.International journal of general medicine · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundQuantitative magnetic resonance imaging (qMRI), such as T1ρ and T2 mapping, allows for the characterization of the biochemical composition of cartilage and the detection of early degeneration within 1 year after anterior cruciate ligament reconstruction (ACLR). It remains unclear if early imaging biomarkers are associated with the long-term development of posttraumatic osteoarthritis (PTOA). HYPOTHESIS/PURPOSE: The study aimed to investigate the relationship between qMRI-based evaluation of the medial compartment at baseline and 1 year after ACLR and the knee joint morphological status using 3-dimensional (3D) MRI at a 10-year follow-up. It was hypothesized that elevated T1p and T2 values at 1 year after ACLR would correlate with increased degenerative joint disease at 10 years after ACLR. STUDY
designCohort study; Level of evidence, 3.
methodsPatients with ACLR between 2011 and 2014 who had preoperative bilateral qMRI were included. Thirteen patients completed the 10-year follow-up and were evaluated. The mean T1ρ and T2 values at baseline and 1 year were obtained using in-house-developed software with MATLAB. The MRI scans at the 10-year follow-up were acquired using a 3-T MRI scanner, including bilateral 3D proton-density fat-saturated fast-spin-echo sequence. Two radiologists used the modified Whole-Organ Magnetic Resonance Imaging Score (WORMS) to grade the images. The correlations between baseline, 1-year, and delta (1 year - baseline) T1ρ/T2 values and the WORMS at 10 years postoperatively were analyzed using the Spearman correlation coefficient. Significance was defined as a
resultsThe baseline, 1-year, and delta medial tibia (MT) T1ρ values were significantly associated with the 10-year WORMS Total Score (
conclusionThe T1ρ/T2 values 1 year postoperatively and the increase from baseline to 1 year in the MT cartilage after ACLR were associated with the deterioration of the comprehensive evaluation of the knee at 10 years postoperatively. These findings help establish qMRI as a valuable biomarker for detecting early signs of PTOA progression.
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