Evidence map›Paper›PMID 40887881›Full record

Trial reportJournal of cosmetic dermatology2025

Assessing the Therapeutic Efficacy of Photodynamic Therapy, Fractional CO

Hamed Abdou, Muhammad Mohsen, Mostafa Taha Eldestawy, Shady Mahmoud Attia Ibrahim

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hamed AbdouAl-Azhar Faculty of Medicine, Cairo, Egypt.ORCID https://orcid.org/0000-0002-2442-8728
Muhammad MohsenAl-Azhar Faculty of Medicine, Cairo, Egypt.
Mostafa Taha EldestawyAl-Azhar Faculty of Medicine, Cairo, Egypt.
Shady Mahmoud Attia IbrahimAl-Azhar Faculty of Medicine, Cairo, Egypt.ORCID https://orcid.org/0000-0001-7616-267X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOnychomycosis, a common fungal nail infection, poses challenges for traditional treatments due to long durations, liver toxicity risks, resistance, and poor nail penetration. So, alternative management approaches, which could involve combination therapy or methods to enhance topical drug delivery for optimal treatment efficacy, should be considered.

aimsThis study evaluates the effectiveness of combining photodynamic therapy (PDT) with fractional CO PATIENTS/

methodsForty-five patients with onychomycosis were included in the study. Patients were randomly assigned to three groups: PDT alone, fractional CO

resultsThe combined therapy group showed the best results, with 86.7% testing negative for onychomycosis and 26.7% achieving full nail clearance. Posttreatment satisfaction levels showed no significant differences among groups (p = 0.198).

conclusionThe combination of PDT and fractional CO

Indexed as

Foot DermatosesLasers, GasOnychomycosisPhotochemotherapyAdultAgedCombined Modality TherapyFemaleHumansLow-Level Light TherapyMaleMiddle AgedPatient SatisfactionPhotosensitizing AgentsTreatment OutcomeYoung AdultPhotosensitizing Agentsantifungal treatmentcombination therapydermatologyfractional CO2 lasernail infectiononychomycosisphotodynamic therapy

Identifiers

PMID40887881
PMCPMC12399919

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.