Evidence map›Paper›PMID 40887803›Full record

ArticleOral diseases2026

Can Large Artificial Intelligence-Based Linguistic Models Help to Obtain Information About Burning Mouth Syndrome?

Paula Benito López, Daniela Adamo, Vito Carlo Alberto Caponio, José González-Serrano, Alan Roger Dos Santos Silva, Miguel de Pedro Herráez, Rui Albuquerque, María Pía López Jornet, Vlaho Brailo, Arwa Farag and 5 more

Abstract read
In one paragraph

Article in Oral diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Paula Benito LópezDepartment of Dental Clinical Specialties, ORALMED Research Group, Complutense University, Madrid, Spain.ORCID https://orcid.org/0009-0005-8518-9299
Daniela AdamoDepartment of Life Sciences, Health and Health Professions, Link Campus University, Rome, Italy.ORCID https://orcid.org/0000-0002-3784-4229
Vito Carlo Alberto CaponioDepartment of Life Sciences, Health and Health Professions, Link Campus University, Rome, Italy.ORCID https://orcid.org/0000-0001-5080-5921
José González-SerranoDepartment of Dental Clinical Specialties, ORALMED Research Group, Complutense University, Madrid, Spain.
Alan Roger Dos Santos SilvaOral Diagnosis Department, Piracicaba Dental School, University of Campinas, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-2040-6617
Miguel de Pedro HerráezOrofacial Pain, Oral Pathology and Dental Sleep Medicine Research Group, Department of Postgraduate Clínical Dentistry, Faculty of Biomedical Sciences, European University of Madrid, Madrid, Spain.ORCID https://orcid.org/0000-0002-7873-8000
Rui AlbuquerqueOral Medicine, Guy's & St Thomas' NHS Foundation Trust (GSTT), Guy's Hospital, London, UK.ORCID https://orcid.org/0000-0002-1741-8871
María Pía López JornetDepartment of Dermatology, Stomatology, Radiology and Physical Medicine, Faculty of Medicine, University of Murcia, Murcia, Spain.ORCID https://orcid.org/0000-0002-3314-8613
Vlaho BrailoDepartment of Oral Medicine, University of Zagreb, School of Dental Medicine, University Clinical Hospital Centre Zagreb, Zagreb, Croatia.ORCID https://orcid.org/0000-0002-8449-871X
Arwa FaragDepartment of Oral Diagnostic Sciences, Faculty of Dentistry, King Abdul Aziz University, Jeddah, Saudi Arabia.ORCID https://orcid.org/0000-0003-3762-3474
Márcio Diniz FreitasSpecial Care Dentistry Unit, University of Santiago de Compostela, Santiago de Compostela, Spain.ORCID https://orcid.org/0000-0001-5349-1091
Noburo NomaDepartment of Oral Medicine, Nihon University School of Dentistry, Tokyo, Japan.ORCID https://orcid.org/0000-0001-5405-0407
Richeal Ni RiordainCork University Dental School and Hospital, University College Cork, Cork, Ireland.
Gonzalo HernándezDepartment of Dental Clinical Specialties, ORALMED Research Group, Complutense University, Madrid, Spain.
Rosa María López-PintorDepartment of Dental Clinical Specialties, ORALMED Research Group, Complutense University, Madrid, Spain.ORCID https://orcid.org/0000-0002-5727-0920

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveBurning Mouth Syndrome (BMS) is an idiopathic chronic orofacial pain disorder with diagnostic and therapeutic challenges. Inexperienced clinicians may desperately resort to online information. The objective of this study was to evaluate the usefulness, quality, and readability of responses generated by three artificial intelligence large language models (AI-LLMs)-ChatGPT-4, Gemini, and Microsoft Copilot-to frequent questions about BMS. MATERIALS AND

methodsNine clinically relevant open-ended questions were identified through search-trend analysis and expert review. Standardized prompts were submitted, and responses were independently rated by 12 international experts using a 4-point usefulness scale. Quality was evaluated using the QAMAI tool. Readability was measured using Flesch-Kincaid Grade Level and Reading Ease scores. Statistical analyses included Kruskal-Wallis and Bonferroni correction.

resultsAll AI-LLMs produced moderately useful responses, with no significant difference in global performance. Gemini achieved highest overall quality scores, particularly in relevance, completeness, and source provision. Copilot scored lower in usefulness and source provision. No significant differences were obtained among AI-LLMs. Average readability corresponded to 12th grade, with ChatGPT requiring the highest proficiency.

conclusionsAI-LLMs show potential for generating reliable information on BMS, though variability in quality, readability, and source citation remains concerning. Continuous optimization is essential to ensure their clinical integration.

Indexed as

Artificial IntelligenceBurning Mouth SyndromeComprehensionGenerative Artificial IntelligenceHumansLarge Language Modelsartificial intelligenceburning mouth syndromelarge language modelsoral medicineorofacial pain

Identifiers

PMID40887803
PMCPMC13248577

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.