Evidence map›Paper›PMID 40887773›Full record

Observational studyRespirology (Carlton, Vic.)2026

Association Between Single Nucleotide Polymorphisms and Disease Susceptibility, Survival, and Acute Exacerbation in Idiopathic Pulmonary Fibrosis.

Kazuya Tsubouchi, Toyoshi Yanagihara, Fumiaki Kiyomi, Yuzo Yamamoto, Masako Arimura-Omori, Naoki Hamada, Katsuyuki Ichiki, Shohei Takata, Hiroshi Ishii, Yasuhiko Kitasato and 9 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Respirology (Carlton, Vic.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Kazuya TsubouchiDepartment of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.ORCID 0000-0003-0145-8745
Toyoshi YanagiharaDepartment of Respiratory Medicine, Fukuoka University School of Medicine, Fukuoka, Japan.ORCID 0000-0002-2212-0631
Fumiaki KiyomiClinical Research Support Center Kyushu, Fukuoka, Japan.
Yuzo YamamotoDepartment of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Masako Arimura-OmoriDepartment of Respiratory Medicine, Japan Community Health Care Organization Kyushu Hospital, Kitakyushu, Japan.
Naoki HamadaDepartment of Respiratory Medicine, Fukuoka University School of Medicine, Fukuoka, Japan.
Katsuyuki IchikiKirigaoka Tsuda Hospital, Kitakyushu, Japan.
Shohei TakataDepartment of Respiratory Diseases, NHO Fukuokahigashi Medical Center, Koga, Japan.
Hiroshi IshiiDepartment of Respiratory Medicine, Fukuoka University Chikushi Hospital, Chikushino, Japan.ORCID 0000-0002-2143-5922
Yasuhiko KitasatoDepartment of Respiratory Medicine, Japan Community Health Care Organization Kurume General Hospital, Kurume, Japan.
Masaki OkamotoDivision of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan.ORCID 0000-0002-9298-3504
Satoru KawakamiDivision of Respiratory Medicine, Kyushu Rosai Hospital, Kitakyushu, Japan.
Kazuhiro YateraDepartment of Respiratory Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.ORCID 0000-0002-2955-4432
Masayuki KawasakiDepartment of Respiratory Diseases, NHO Omuta National Hospital, Omuta, Japan.
Masaki FujitaDepartment of Respiratory Medicine, Fukuoka University School of Medicine, Fukuoka, Japan.
Shoji TokunagaMedical Information Center, Kyushu University Hospital, Fukuoka, Japan.
Chikako KiyoharaDepartment of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yoichi NakanishiKitakyushu City Hospital Organization, Kitakyushu, Japan.
Isamu OkamotoDepartment of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.ORCID 0000-0002-7587-6096

Funding

Boehringer IngelheimThe Diffuse Lung Diseases Research Group from the Ministry of Health, Labor, and Welfare of JapanThe Ministry of Education, Culture, Sports, Science, and Technology of Japan for a broad-area, network-based project to drive clinical research at Kyushu University Hospital
6 · The paper itself

Abstract

BACKGROUND AND

objectiveGenetic polymorphisms have been associated with susceptibility to interstitial lung diseases including idiopathic pulmonary fibrosis (IPF). We have now examined the relation between single nucleotide polymorphisms (SNPs) and clinical course, including acute exacerbation (AE), in addition to disease susceptibility for IPF and unclassifiable idiopathic interstitial pneumonias (IIPs).

methodsDNA samples were collected from 223 IPF patients and 160 unclassifiable IIP patients included in a prospective, multicentre observational study in Japan. Nonfibrotic control subjects (n = 379) were selected from a previous study. Genotyping of TERT rs2736100, TERC rs1881984, MUC5B rs35705950, DSP rs2076295, and AKAP13 rs62025270 was conducted with commercial assays. The association between these SNPs and disease susceptibility, prognosis, or the cumulative incidence of AE was assessed.

resultsTERT rs2736100 and MUC5B rs35705950 were significantly associated with IPF risk, and DSP rs2076295 was linked to prognosis and the incidence of AE in IPF patients. TERT rs2736100 was significantly associated with prognosis in IPF patients and the incidence of AE in patients with unclassifiable IIPs. No individuals with the TT genotype of MUC5B rs35705950 were identified, and the proportion of those with the T allele was low (minor allele frequency of 0.005 in control subjects). In addition, no individuals with the minor allele (A) of AKAP13 rs62025270 were detected.

conclusionConsideration of genetic polymorphisms has the potential to facilitate prediction not only of prognosis but also of AE in individuals with IIPs, providing a foundation for the development of personalised management strategies based on genetic profiles.

Indexed as

Genetic Predisposition to DiseaseIdiopathic Pulmonary FibrosisPolymorphism, Single NucleotideAgedA Kinase Anchor ProteinsCase-Control StudiesDisease ProgressionFemaleGenotypeHumansIdiopathic Interstitial PneumoniasJapanMaleMiddle AgedMucin-5BPrognosisA Kinase Anchor ProteinsMUC5B protein, humanMucin-5BTelomeraseTERT protein, humanacute exacerbationdesmoplakinidiopathic pulmonary fibrosissingle nucleotide polymorphismstelomere

Identifiers

PMID40887773
PMCPMC12783960

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.