ReviewGut microbes2025
Review: microbial metabolites - a key to address gut inflammation and barrier dysfunction in the premature infant.
Review in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Maternal and infant gut microbiome.iMeta · 2026Review
- Reconceptualizing chorioamnionitis as an immune-mediated inflammatory disorder at the maternal-fetal interface.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Advancing child health: forecasting the next great research achievements.Pediatric research · 2026Article
- Priming innate immunity and long-term outcome.Molecular and cellular pediatrics · 2026Review
- Does genetic susceptibility play a role in necrotizing enterocolitis?Pediatric research · 2026Article
- Synergistic regulation of gut microbiota and metabolites by breast milk and probiotics in the prevention of neonatal necrotizing enterocolitis: mechanisms and prospects.Translational pediatrics · 2026Review
- Mechanisms by which tryptophan metabolites enhance intestinal barrier function to prevent necrotizing enterocolitis in preterm infants.Frontiers in immunology · 2026Review
- Integrated multi-omics analysis reveals dendritic cell centered regulatory networks and therapeutic targets in necrotizing enterocolitis.Frontiers in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Preterm birth interrupts the development of the human gastrointestinal tract, resulting in an immature permeable gut barrier with increased risk of intestinal pathology, such as necrotizing enterocolitis (NEC). The gut microbiota metabolize dietary components into bioactive metabolites that play a crucial role in maintaining intestinal homeostasis. While the roles of microbial metabolites have been studied in relation to adult gastrointestinal diseases, their specific impact on preterm infants remains unexplored. This review aims to identify how microbial metabolites interact with the developing gut barrier in preterm infants, focusing on their role in gut inflammation and NEC. Metabolites include short-chain and conjugated fatty acids, indole derivatives, bile acids, polyamines, and polyphenolic compounds. An overview of the unique features of the premature gut barrier physiology is provided, including perinatal developmental changes in cellular structure, cell junctions, and the gut microbiome. Potential benefits and molecular mechanisms of microbial metabolites in the premature intestine and environmental factors responsible for NEC are discussed. In summary, microbiome-derived mediators have the potential to strengthen preterm gut barrier integrity and alleviate inflammatory stress. Further research may reveal clinically relevant preventative or therapeutic treatment targets for NEC in preterm infants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.