Evidence map›Paper›PMID 40887738›Full record

ArticlePhotochemistry and photobiology

Constitutive nitric oxide synthases deficiency impairs cyclobutane pyrimidine dimer repair following solar UV exposure in cells and mice.

Veronica Bahamondes Lorca, Yuxi Zhou, Christina Athans, Hailey Payne, Madison Wright, Zeinab Feyyaz, Lingying Tong, Dawn L Sammons, Shiyong Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Photochemistry and photobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Veronica Bahamondes LorcaDepartment of Chemistry and Biochemistry, Ohio University, Athens, Ohio, USA.ORCID 0000-0002-0488-2472
Yuxi ZhouDepartment of Chemistry and Biochemistry, Ohio University, Athens, Ohio, USA.
Christina AthansHonor Tutorial College, Ohio University, Athens, Ohio, USA.
Hailey PayneHonor Tutorial College, Ohio University, Athens, Ohio, USA.
Madison WrightDepartment of Chemistry and Biochemistry, Ohio University, Athens, Ohio, USA.
Zeinab FeyyazDepartment of Chemistry and Biochemistry, Ohio University, Athens, Ohio, USA.
Lingying TongDepartment of Chemistry and Biochemistry, Ohio University, Athens, Ohio, USA.
Dawn L SammonsOakview Dermatology, Athens, Ohio, USA.
Shiyong WuDepartment of Chemistry and Biochemistry, Ohio University, Athens, Ohio, USA.ORCID 0000-0002-4104-4160

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
Molecular mechanisms of cNOS-mediated NF-kappa B activation in regulation of ultraviolet B light-induced photocarcinogenic responsesR01ES030425 · NIEHS · OHIO UNIVERSITY ATHENS · PI WU, SHIYONG · 2019 to 2023
$1.7M
NCI NIH HHS P30 CA016086NIEHS NIH HHS ES030425NIEHS NIH HHS R01 ES030425
6 · The paper itself

Abstract

Solar ultraviolet (sUV) radiation is a major environmental factor that induces DNA damage, promoting skin aging and carcinogenesis. The formation of cyclobutane pyrimidine dimers (CPDs) is one of the most prevalent forms of UV-induced DNA lesions, playing a central role in skin photocarcinogenesis. Constitutive nitric oxide synthase (cNOS), responsible for basal nitric oxide (NO

Indexed as

DNA RepairNitric Oxide SynthasePyrimidine DimersUltraviolet RaysAnimalsDNA DamageFibroblastsHEK293 CellsHumansMiceMice, KnockoutSkinNitric Oxide SynthasePyrimidine Dimersconstitutive nitric oxide synthase (cNOS)DNA damageDNA repairphotocarcinogenesissolar ultraviolet radiation (sUV)

Identifiers

PMID40887738
PMCPMC12981231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.