Trial reportAddiction (Abingdon, England)2026
A pilot randomized controlled trial of Kisoboka, a behavioral economic and motivational interviewing intervention to reduce high-risk alcohol use and improve antiretroviral therapy adherence for men in Uganda.
Trial report in Addiction (Abingdon, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The trial behind it
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Who cites it
1 citing paper in PubMed.
- Alcohol Use Disorder in Southwestern and Northern Uganda: Prevalence and associated factors.PLOS global public health · 2026Article
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Authors and funding
13 authors.
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Abstract
aimsWe assessed the feasibility and preliminary efficacy of a multilevel intervention (Kisoboka) to reduce high-risk alcohol use and improve human immunodeficiency virus (HIV) treatment engagement among fisherfolk men in Uganda.
designA parallel individually randomized controlled pilot trial with follow-up at 3 and 6 months.
settingFive HIV clinics near Ugandan fishing communities.
participants160 men (80 per arm), aged 18-50, living with HIV, reporting suboptimal antiretroviral therapy (ART) adherence and high-risk alcohol use, enrolled between January 2021 and March 2022.
interventionKisoboka applies behavioral economic principles and motivational interviewing to address contextual determinants of alcohol use and suboptimal HIV treatment through counseling sessions, text reminders about savings and health goals, and a structural component of assistance setting up mobile money accounts and use of mobile money to receive work pay. The comparator arm (S&R) received only brief alcohol screening feedback, referrals for alcohol counseling and HIV treatment counseling. MEASUREMENTS: High-risk alcohol use assessed via phosphatidylethanol (PEth) level at baseline and 6 months and Alcohol Use Disorders Identification Test - Consumption (AUDIT-C) (cutoff ≥9) at baseline, 3 and 6 months. Self-reported ART adherence (≥90% versus <90%) assessed at baseline, 3 and 6 months. SECONDARY OUTCOMES: number of days with ≥5 drinks in the prior 28 days and HIV viral load. We assessed intervention fidelity by audio recording and transcribing sessions, then coding a random 20% sample for fidelity to protocol elements.
findingsRetention (92.5% completed all sessions) and fidelity (92.8-100% across sessions) were high. Relative to the comparator arm, PEth values decreased from baseline to 6-month follow-up in the Kisoboka arm [difference in change -126.87 ng/ml, 95% confidence interval (CI) = -264.29 to 10.55], which was a small effect size (adjusted time* arm interaction: d = 0.14). The proportion with AUDIT-C ≥9 decreased more in the Kisoboka arm between baseline and 6 months (-26.01%, 95% CI = -36.09% to -15.93%), a medium effect size time*arm effect (d = 0.68). Kisoboka did not improve adherence but protected against declines in optimal adherence observed in the S&R arm (difference in change: 20.96%, 95% CI = 7.15% to 34.77%), which was a medium effect size time*arm effect (d = 0.51).
conclusionsThe Kisoboka multilevel intervention to reduce high-risk alcohol use appears to be feasible; it showed promising clinically meaningful small to medium size effects on reducing high-risk alcohol use and protected against decreases in antiretroviral therapy adherence in a setting with strong contextual determinants of behavior.
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