Evidence map›Paper›PMID 40887546›Full record

Observational studyEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Management of inner ear schwannomas with cochlear involvement in a tertiary referral centre: a retrospective clinical study.

Luisa Mattalia, Hannah Daoudi, Matteo Di Bari, Isabelle Mosnier, Frederic Tankere, Olivier Sterkers, Lucia Oriella Piccioni, Daniele Bernardeschi, Lauranne Alciato

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Luisa MattaliaService d'Otorhinolaryngologie et Chirurgie Cervico-Faciale, GH Pitié- Salpêtrière, AP-HP Sorbonne Université, Paris, France.
Hannah DaoudiService d'Otorhinolaryngologie et Chirurgie Cervico-Faciale, GH Pitié- Salpêtrière, AP-HP Sorbonne Université, Paris, France.
Matteo Di BariService d'Otorhinolaryngologie et Chirurgie Cervico-Faciale, GH Pitié- Salpêtrière, AP-HP Sorbonne Université, Paris, France.
Isabelle MosnierService d'Otorhinolaryngologie et Chirurgie Cervico-Faciale, GH Pitié- Salpêtrière, AP-HP Sorbonne Université, Paris, France.
Frederic TankereService d'Otorhinolaryngologie et Chirurgie Cervico-Faciale, GH Pitié- Salpêtrière, AP-HP Sorbonne Université, Paris, France.
Olivier SterkersService d'Otorhinolaryngologie et Chirurgie Cervico-Faciale, GH Pitié- Salpêtrière, AP-HP Sorbonne Université, Paris, France.
Lucia Oriella PiccioniUnità Operativa di Otorinolaringoiatria e Chirurgia Cervico-Faciale, IRCCS Ospedale san Raffaele, Milano, Italy.
Daniele BernardeschiService d'Otorhinolaryngologie et Chirurgie Cervico-Faciale, GH Pitié- Salpêtrière, AP-HP Sorbonne Université, Paris, France. daniele.bernardeschi@aphp.fr.ORCID http://orcid.org/0000-0002-5937-8847
Lauranne AlciatoService d'Otorhinolaryngologie et Chirurgie Cervico-Faciale, GH Pitié- Salpêtrière, AP-HP Sorbonne Université, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA retrospective observational study in a tertiary otologic referral centre was conducted in to analyse a case series of 33 patients with inner ear schwannoma and cochlear involvement (intracochlear, intravestibulocochlear, or transfundal with modiolar involvement) and report the results of different treatment modalities.

methodsWe included consecutive patients with inner ear schwannoma and cochlear involvement (intracochlear, intravestibulocochlear, or transfundal with modiolar involvement). Data collectedincluded demographic data, presenting symptoms, audiometric results, radiological characteristics of the tumour at presentation and at follow-up visits, and treatment modalities.

resultsWe included 33 adults with schwannoma; 17 (51%) were men. The mean age at diagnosis was 55 ± 13.1 years. Twenty-four patients (73%) had intracochlear, 5 (15%) transfundal with modiolar involvement, 2 (6%) intravestibulocochlear schwannoma. Two (6%) schwannomas involved the cerebellopontine angle. Concerning symptoms at diagnosis, 28 on 33 patients audiometric datas were available; in these cases, all patients presented some degree of hearing loss. One patient had spontaneous facial paralysis. Twenty-eight (85%) underwent "wait-and-scan" management, during which hearing worsened to AAO-HNS class D for 6 (21%), 15 (54%) showed some degree of tumour growth, 2 (7%) developed spontaneous facial paralysis. All 3 patients with spontaneous facial paralysis had a tumour involving the internal auditory canal. Eleven of 28 patients (39%) underwent surgery after an initial wait-and-scan management (median follow-up of 50 months). Five patients (15%) elected immediate microsurgery tumour removal. Two patients underwent cochlear implantation: one patient did not use the device and had not achieved satisfactory audiometric results The other one exhibited good audiometric results after 3 months (PTA = 30 dB, Speech Discrimination Score = 100% at 70 dB). Complications were rare and minor; no patients showed residual tumour or recurrence.

conclusionsA wait-and-scan policy is the preferred treatment if patients have serviceable hearing. With AAO-HNS class D hearing, microsurgical removal is advised: tumours extending to the internal auditory canal were associated with risk of spontaneous facial paralysis. Surgery is safe and effective. A simultaneous cochlear implant could be proposed.

Indexed as

CochleaEar NeoplasmsNeurilemmomaNeuroma, AcousticAdultAgedFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesTertiary Care CentersTreatment OutcomeCochlear implantationFacial palsyIntracochlear SchwannomaNeurotologyOtosurgery

Identifiers

PMID40887546

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.