Evidence map›Paper›PMID 40887545›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Concurrent chemoradiotherapy with docetaxel, cisplatin, and fluorouracil for patients with advanced external auditory canal squamous cell carcinoma: comparison with cisplatin-based concurrent chemoradiotherapy.

Yushi Ueki, Yuki Ohno, Shusuke Ohshima, Yusuke Yokoyama, Jo Omata, Takeshi Takahashi, Ryusuke Shodo, Kohei Saijo, Kohei Ohtaki, Hiroshi Matsuyama and 4 more

Abstract readComparative Study
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In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yushi UekiDepartment of Otolaryngology Head and Neck Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan. ucuekin@gmail.com.ORCID http://orcid.org/0000-0002-1699-7891
Yuki OhnoDepartment of Otolaryngology Head and Neck Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Shusuke OhshimaDepartment of Otolaryngology Head and Neck Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Yusuke YokoyamaDepartment of Otolaryngology Head and Neck Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Jo OmataDepartment of Otolaryngology Head and Neck Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Takeshi TakahashiDepartment of Otolaryngology Head and Neck Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Ryusuke ShodoDepartment of Otolaryngology Head and Neck Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Kohei SaijoDepartment of Otolaryngology Head and Neck Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Kohei OhtakiDepartment of Otorhinolaryngology, Niigata General Hospital, Niigata City, Niigata, Japan.
Hiroshi MatsuyamaDepartment of Otorhinolaryngology, Niigata General Hospital, Niigata City, Niigata, Japan.
Riku AoyamaDepartment of Otorhinolaryngology, Niigata Prefectural Central Hospital, Joetsu City, Niigata, Japan.
Manabu OgiDepartment of Otorhinolaryngology, Niigata Prefectural Central Hospital, Joetsu City, Niigata, Japan.
Nao TakahashiDepartment of Otorhinolaryngology, Nagaoka Red Cross Hospital, Nagaoka City, Niigata, Japan.
Arata HoriiDepartment of Otolaryngology Head and Neck Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeConcurrent chemoradiotherapy (CCRT) with docetaxel, cisplatin (CDDP), and fluorouracil (5-FU) (i.e. TPF regimen) has yielded favourable outcomes in treating advanced external auditory canal squamous cell carcinoma (EACSCC). However, safety and efficacy have not been compared across TPF-CCRT and CDDP-based regimens. This study thus aimed to assess the feasibility, safety, and efficacy of TPF-CCRT versus CDDP-CCRT.

methodsThis retrospective study evaluated 20 patients with T3/T4 EACSCC who underwent CCRT between 2007 and 2023. During radiotherapy, the TPF group (n = 10) received two cycles of 50 mg/m

resultsAll patients completed radiotherapy. The incidence of grade ≥ 3 adverse events was not significantly different between the TPF and CDDP groups, but leukopenia (any grade) and alopecia occurred more frequently in the TPF group. Two-year PFS (80% vs. 20%, p < 0.01) and OS rates (100% vs. 40%, p < 0.01) were significantly higher in the TPF group.

conclusionCompared with CDDP-CCRT, TPF-CCRT has excellent feasibility and efficacy and acceptable toxicity for advanced EACSCC, making it a promising treatment option for this malignancy.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsCarcinoma, Squamous CellChemoradiotherapyEar CanalEar NeoplasmsAdultAgedCisplatinDocetaxelFeasibility StudiesFemaleFluorouracilHumansMaleMiddle AgedNeoplasm StagingCisplatinDocetaxelFluorouracil5-FUCisplatinCisplatin-based regimenConcurrent chemoradiotherapyDocetaxelExternal auditory canal squamous cell carcinoma

Identifiers

PMID40887545

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.