Evidence map›Paper›PMID 40887471›Full record

ArticleCommunications biology2025

Food insecurity impacts neuroblastoma pathogenesis in murine xenograft tumor models.

Keyonna Williams, Sahiti Chukkapalli, Biao Hu, Delawrence Sykes, Kimber Converso-Baran, Olivia Tussing, Anjalika Dandamudi, Payton Thayer, Kendal Donnelly, Samantha Kaminsky and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Keyonna Williams *Department of Surgery, Section of Pediatric Surgery, The Rogel Cancer Center, The University of Michigan Medical School, Ann Arbor, MI, USA.
Sahiti Chukkapalli *Department of Surgery, Section of Pediatric Surgery, The Rogel Cancer Center, The University of Michigan Medical School, Ann Arbor, MI, USA.
Biao HuDepartment of Surgery, Section of Pediatric Surgery, The Rogel Cancer Center, The University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-4691-6490
Delawrence SykesDepartment of Biology, Berry College, Mount Berry, GA, USA.
Kimber Converso-BaranPhysiology and Phenotype Center, Frankel Cardiovascular Center, The University of Michigan Medical School, Ann Arbor, MI, USA.
Olivia TussingDepartment of Surgery, Section of Pediatric Surgery, The Rogel Cancer Center, The University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-2357-4168
Anjalika DandamudiDepartment of Surgery, Section of Pediatric Surgery, The Rogel Cancer Center, The University of Michigan Medical School, Ann Arbor, MI, USA.
Payton ThayerDepartment of Surgery, Section of Pediatric Surgery, The Rogel Cancer Center, The University of Michigan Medical School, Ann Arbor, MI, USA.
Kendal DonnellyDepartment of Surgery, Section of Pediatric Surgery, The Rogel Cancer Center, The University of Michigan Medical School, Ann Arbor, MI, USA.
Samantha KaminskyDepartment of Surgery, Section of Pediatric Surgery, The Rogel Cancer Center, The University of Michigan Medical School, Ann Arbor, MI, USA.
Benjamin CurtisUnit for Laboratory Animal Medicine, In-Vivo Animal Core, The University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-5165-0167
Yatrik ShahDepartment of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, MI, USA.
Kenneth ResnicowDepartment of Pediatrics, The Rogel Cancer Center, The School of Public Health, The University of Michigan Medical School, Ann Arbor, MI, USA.
Erika A NewmanDepartment of Surgery, Section of Pediatric Surgery, The Rogel Cancer Center, The University of Michigan Medical School, Ann Arbor, MI, USA. eanewman@med.umich.edu.ORCID http://orcid.org/0000-0003-3999-0323
Project on Poverty in Neuroblastoma Evolution (PINE) Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A recent landmark study by the National Cancer Institute's Children's Oncology Group identified an independent association between childhood poverty and increased mortality rates in children with neuroblastoma, beyond known biological, access, or treatment variables. Neuroblastoma, a prevalent extracranial nervous system tumor in children, is influenced by both biological and environmental factors. Recent studies suggest a direct link between poverty and poorer cancer survival outcomes, yet the biological mechanisms underlying this influence remain poorly understood. We hypothesize that socioeconomic stressors like food insecurity significantly impact neuroblastoma progression. To investigate this, we developed a murine model that simulates socioeconomic challenges by varying chow accessibility to mimic food insecurity. Our results demonstrate that food insecurity significantly accelerates neuroblastoma tumor growth and metastatic spread compared to controls. This exacerbation of tumor burden in food-insecure mice underscores the potential influence of socioeconomic stressors on cancer dynamics and challenges the traditional focus on genetic and biological factors alone. Our findings highlight the crucial role of socioeconomic factors in tumor biology and advocate for a more holistic approach that integrates socioeconomics and social determinants into therapeutic strategies.

Indexed as

Food InsecurityNeuroblastomaAnimalsCell Line, TumorDisease Models, AnimalFemaleHumansMaleMice

Identifiers

PMID40887471
PMCPMC12399758

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.