Evidence map›Paper›PMID 40887440›Full record

ReviewAmerican journal of critical care : an official publication, American Association of Critical-Care Nurses2025

From Ancient Enemas to Tube Feeding, I: History, Administration, and Nutritional Composition of Commercial Versus Food-Based Formulas in Critical Illness.

Sanil N Gandhi, Yeonsu Song, Matthew J Landry, Atul Malhotra, Rohit Loomba, Jennifer L Martin, Biren B Kamdar

Abstract readHistorical ArticleReview
In one paragraph

Review in American journal of critical care : an official publication, American Association of Critical-Care Nurses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. From Ancient Enemas to Tube Feeding, II: Clinical Outcomes and Future Directions Surrounding Commercial Versus Food-Based Formulas in Critical Illness.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sanil N GandhiSanil N. Gandhi was a medical student at Boston University School of Medicine, Massachusetts, during the writing of this article and is currently a resident in internal medicine at the University of California, Irvine.
Yeonsu SongYeonsu Song is an associate professor, School of Nursing, University of California, Los Angeles, an adjunct associate professor, Department of Medicine, University of California, Los Angeles, and an affiliated investigator, Geriatric Research, Education, and Clinical Center, Greater Los Angeles VA Healthcare System, Los Angeles, California.
Matthew J LandryMatthew J. Landry is an assistant professor, Department of Population Health and Disease Prevention, Joe C. Wen School of Population & Public Health, University of California, Irvine, Irvine, California.
Atul MalhotraAtul Malhotra is a professor of medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of California, San Diego, La Jolla, California.
Rohit LoombaRohit Loomba is a research director, MASLD Research Center, Division of Gastroenterology and Hepatology, Department of Medicine, and a professor of medicine and chief, Division of Gastroenterology and Hepatology, University of California, San Diego, La Jolla, California.
Jennifer L MartinJennifer L. Martin is a professor, Department of Medicine, University of California, Los Angeles, and associate director, Geriatric Research, Education, and Clinical Center, Greater Los Angeles VA Healthcare System, Los Angeles, California.
Biren B KamdarBiren B. Kamdar is an associate professor, Division of Pulmonary, Critical Care, and Sleep Medicine, University of California, San Diego, and a staff physician, Pulmonary and Critical Care, VA San Diego Healthcare System, La Jolla, California.

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
Pediatric Trials in Non-Alcoholic Steatohepatitis (NASH)U01DK061734 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROHIT LOOMBA · 2002 to 2026
$24.4M
Tissue-specific roles of FXR in CVD and NASHP01HL147835 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LOOMBA, ROHIT · 2020 to 2024
$12.2M
San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2019 to 2026
$10.8M
HIV MASLD Clinical Research Network (HCRN)R01DK121378 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI NAGA P CHALASANI, ROHIT LOOMBA · 2020 to 2026
$8.7M
Novel IL-23 inhibitor for the treatment of alcohol associated liver diseaseU01AA029019 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KISSELEVA, TATIANA, LOOMBA, ROHIT · 2020 to 2024
$3.7M
Is Obstructive Sleep Apnea Important in the Development of Alzheimer's DiseaseR01AG063925 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2020 to 2024
$3.7M
Underlying mechanisms of obesity-induced obstructive sleep apneaR01HL148436 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2020 to 2026
$3.4M
QUS Technology for Diagnosis and Grading of Hepatic Steatosis in NAFLDR01DK106419 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LOOMBA, ROHIT, SIRLIN, CLAUDE B · 2015 to 2019
$3.4M
Sleep Apnea Endophenotypes: One Size Does Not Fit AllR01HL154926 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2021 to 2025
$3.3M
The cardiovascular consequences of sleep apnea plus COPD (Overlap syndrome)R01HL166485 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2023 to 2026
$3.1M
VentNet: A Real-Time Multimodal Data Integration Model for Prediction of Respiratory Failure in Patients with COVID-19R01HL157985 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, NEMATI, SHAMIM · 2022 to 2025
$2.9M
NCATS NIH HHS UL1 TR001442NHLBI NIH HHS K24 HL143055NHLBI NIH HHS P01 HL147835NHLBI NIH HHS R01 HL148436NHLBI NIH HHS R01 HL154926NHLBI NIH HHS R01 HL157985NHLBI NIH HHS R01 HL166485NHLBI NIH HHS T32 HL166127NIAAA NIH HHS U01 AA029019NIA NIH HHS K76 AG059936NIA NIH HHS R01 AG063925NIDDK NIH HHS P30 DK120515NIDDK NIH HHS R01 DK106419NIDDK NIH HHS R01 DK121378NIDDK NIH HHS R01 DK124318NIDDK NIH HHS U01 DK061734NIDDK NIH HHS U01 DK130190
6 · The paper itself

Abstract

During critical illness, tube feedings are used to provide vital nutrition for patients unable to obtain adequate oral intake. Part I of this 2-part review article series examines the history, delivery, and content of enteral formulas in the intensive care unit. Food-based tube feedings date back to ancient times when ill patients received nutrition via enemas composed of ingredients such as barley, eggs, and wine. Since the mid-1900s, the landscape has been dominated by commercially prepared ("commercial" or "conventional") formulas-synthetic blends composed of vitamins and minerals mixed with processed proteins, carbohydrates, fats, thickening agents, and shelf-life extenders such as sodium caseinate, maltodextrin, canola oil, and corn syrup. In response to increasing interest in whole foods and their role in illness recovery, food-based formulas have gained popularity as an alternative, supported by the emergence of plant- and food-based blends, growing scientific attention, and inclusion in hospital formularies. Part I provides an overview of the historical evolution of enteral feeding practices, methods of administration, and the nutritional content of commercial versus food-based formulas. In part II, clinical outcomes and future directions will be evaluated. Together, this 2-part series aims to inform prescribing practices and promote patient-centered nutrition strategies in critical care.

Indexed as

Critical IllnessEnteral NutritionFood, FormulatedCritical CareHistory, 17th CenturyHistory, 18th CenturyHistory, 19th CenturyHistory, 20th CenturyHistory, 21st CenturyHistory, AncientHistory, MedievalHumansIntensive Care Units

Identifiers

PMID40887440
PMCPMC12693691

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.