ArticleBMJ open2025
Impact of irritating infusates via midline catheters on vascular complications: a multicentre prospective cohort study protocol in China.
Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06454552 (A Study of Stimulant Medications Infusion Through Midline Catheters Based on Real-world Data), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Study of Stimulant Medications Infusion Through Midline Catheters Based on Real-world Data
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMidline catheters (MCs) longer than 15 cm are increasingly used for intravenous therapy. However, a consensus on the safe administration of irritating infusates (pH <5 or >9, osmolality >900 mOsm/L) is lacking. The current guidelines do not specify how the catheter tip position (axillary vein of the chest wall or subclavian vein) modulates the complication risks. This study investigates the relationship between the tip location, irritant drug properties and vascular injury. METHODS AND ANALYSIS: A multicentre, prospective study involving patients receiving irritating infusates via MCs across 12 Chinese hospitals (stratified random sampling of 12 provinces) will be conducted. Preinsertion ultrasound will assess the vascular anatomy, with postinsertion X-ray confirming the tip position. The primary outcome, intima injury, will be assessed through weekly ultrasound evaluations until catheter removal. Secondary outcomes include phlebitis, thrombosis, occlusion and infection. Associations among tip position, drug physicochemical properties, dwell time and complications will be analysed using multivariable logistic and Cox regression analyses. ETHICS AND DISSEMINATION: The study is approved by the Ethics Committee of the Sir Run Run Shaw Hospital, Zhejiang University School of Medicine (#20240096; 20/02/2024). Results will be disseminated through peer-reviewed publication and international conferences. TRIAL REGISTRATION NUMBER: NCT06454552; Pre-results.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.