Evidence map›Paper›PMID 40887045›Full record

ArticleBritish journal of haematology2025

European-based polygenic risk score and genome-wide association study of B-cell non-Hodgkin lymphoma subtypes in Israeli Jews and Palestinian Arabs.

Geffen Kleinstern, Dennis P Robinson, Rania Abu Seir, Riki Perlman, Jianjun Liu, Nidal Jebrini, Hussein Elyan, Dina Ben Yehuda, Susan L Slager, Ora Paltiel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Geffen KleinsternFaculty of Social Welfare and Health Sciences, School of Public Health, University of Haifa, Haifa, Israel.ORCID https://orcid.org/0000-0001-6148-0421
Dennis P RobinsonDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Rania Abu SeirDepartment of Medical Laboratory Sciences, Al-Quds University, Jerusalem, Palestine.
Riki PerlmanDepartment of Hematology, Hadassah Medical Organization, Jerusalem, Israel.
Jianjun LiuLaboratory of Human Genomics, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.
Nidal JebriniBeit-Jala Hospital, Bethlehem, Palestine.
Hussein ElyanHusein Hematology and Lymphoma Clinic, Bethlehem, Palestine.
Dina Ben YehudaDepartment of Hematology, Hadassah Medical Organization, Jerusalem, Israel.
Susan L SlagerDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Ora PaltielFaculty of Medicine, Braun School of Public Health and Community Medicine, Hadassah-Hebrew University, Jerusalem, Israel.ORCID https://orcid.org/0000-0001-8324-3873

Funding

The genetic and epigenetic etiology of progression from the precursor state to chronic lymphocytic leukemia (CLL)R01CA258465 · NCI · MAYO CLINIC ROCHESTER · PI BRAGGIO, ESTEBAN, OAKES, CHRISTOPHER C. · 2022 to 2025
$4.1M
Germline and Somatic Genomic Studies in CLL MinoritiesR01CA254951 · NCI · MAYO CLINIC ROCHESTER · PI BRAGGIO, ESTEBAN, SLAGER, SUSAN L · 2021 to 2025
$3.3M
Hadassah University Hospital Compensatory FundIsrael Science Foundation 877/10NCI NIH HHS R01 CA254951NCI NIH HHS R01 CA258465United States Agency for International Development (USAID), MERC TA-MOU-11-M31-025
6 · The paper itself

Abstract

Among individuals of European Ancestry (EA), genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) and polygenic risk scores (PRSs) associated with non-Hodgkin lymphoma (NHL) risk. We evaluated subtype-specific PRSs, based on established EA-SNPs, in Israeli Jews (IJ) and Palestinian Arabs (PA) and performed a GWAS in the combined ethnic groups to identify new loci. We included three common pathologically confirmed subtypes: diffuse large B-cell (DLBCL), follicular (FL) and marginal zone (MZL) lymphomas. Controls were frequency matched to cases by age and sex. Among 752 IJ (201-DLBCL; 130-FL; 54-MZL/367-controls) and 593 PA (203-DLBCL; 41-FL/349-controls), we computed PRSs weighted by EA-derived effect estimates and used logistic regression models adjusted for confounders. In the combined ethnic groups of IJ and PA, subtype-specific PRSs were significantly associated with the corresponding subtype, with a 1.69-fold, 2.21-fold and 2.26-fold risk for DLBCL, FL and MZL, respectively; however, these effect sizes were attenuated compared to those reported in EA and varied by ethnicity. In the GWAS of the combined ethnic groups, two novel SNPs in the 6p21.32 locus were associated with DLBCL risk. Additional GWAS studies are needed among Jewish and Arab populations to improve genetic risk prediction for NHL in these ethnic groups.

Indexed as

ArabsGenome-Wide Association StudyJewsMultifactorial InheritanceAdultAgedCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenetic Risk ScoreHumansIsraelLymphoma, Large B-Cell, DiffuseMaleMiddle AgedPolymorphism, Single Nucleotidediffuse large B‐cell lymphomaethnicitygenome‐wide association studynon‐Hodgkin lymphoma subtypespolygenic risk score

Identifiers

PMID40887045
PMCPMC12624183

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.