Evidence map›Paper›PMID 40886950›Full record

ArticleThe Journal of nutrition2025

Sleep Duration Modifies the Association of the Alternate Mediterranean Diet Score With Metabolic Syndrome in Midlife Women in Mexico.

Haneen Bou Ghanem, Maria M Kofas, Karen E Peterson, Alejandra Cantoral, Abeer Aljahdali, Libni Torres-Olascoaga, Martha M Tellez-Rojo, Erica C Jansen

Abstract read
In one paragraph

Article in The Journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Haneen Bou GhanemDepartment of Nutritional Sciences, University of Michigan, Ann Arbor, MI, United States.
Maria M KofasDepartment of Nutritional Sciences, University of Michigan, Ann Arbor, MI, United States.
Karen E PetersonDepartment of Nutritional Sciences, University of Michigan, Ann Arbor, MI, United States.
Alejandra CantoralDepartment of Health, Iberoamerican University, Mexico City, Mexico.
Abeer AljahdaliDepartment of Clinical Nutrition, King Abdulaziz University, Jeddah, Saudi Arabia.
Libni Torres-OlascoagaCenter for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Mexico.
Martha M Tellez-RojoCenter for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Mexico.
Erica C JansenDepartment of Nutritional Sciences, University of Michigan, Ann Arbor, MI, United States. Electronic address: janerica@umich.edu.

Funding

Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RANDY J SEELEY · 2010 to 2026
$20.3M
Metabolic Health Risk Among Mid-Life Women: The Roles of Toxicants, Inflammation, and EpigeneticsR01ES032330 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PETERSON, KAREN EILEEN · 2020 to 2024
$2.9M
E3Gen: Multigenerational Influences of Social Structure on Toxicant Exposures and Life Course Health in the ELEMENT CohortR24ES028502 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Karen Eileen Peterson, Peter Xuekun Song · 2017 to 2026
$2.2M
E3Gen: Multigenerational Influences of Social Structure on Toxicant Exposures and Life Course Health in the ELEMENT CohortU24ES028502 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PETERSON, KAREN EILEEN, SONG, PETER XUEKUN · 2023 to 2025
$1.0M
Sleep and Circadian Rhythms in Adolescence: Epigenetic Pathways of Cardiometabolic RiskK01HL151673 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JANSEN, ERICA CHRISTINE · 2020 to 2024
$759k
NHLBI NIH HHS K01 HL151673NIDDK NIH HHS P30 DK089503NIEHS NIH HHS P30 ES017885NIEHS NIH HHS R01 ES032330NIEHS NIH HHS R24 ES028502NIEHS NIH HHS U24 ES028502
6 · The paper itself

Abstract

backgroundAdherence to a Mediterranean diet and better sleep health have independently been associated with a lower risk of metabolic syndrome (MetS); however, their combined effect has rarely been considered.

objectivesThis study aimed to examine whether sleep duration modifies the association between adherence to the alternate Mediterranean (aMed) diet and MetS among midlife Mexican women.

methodsThe analytic sample consisted of 410 women with a mean age of 48.2 ± 6.1 years participating in the Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) study. Diet was assessed with a validated food frequency questionnaire (FFQ). The mean daily sleep duration was measured with 7-d wrist actigraphy (Actigraph GTX-BT). MetS was defined on the basis of the American Heart Association/National Heart, Lung, and Blood Institute criteria. Multivariable logistic regression models were used to estimate the association between higher adherence to the aMed diet and MetS and between sleep duration and MetS, each controlling for age, socioeconomic status, and moderate-to-vigorous physical activity. To assess the potential modifying role of sleep duration, stratified analysis by sleep status was conducted, where participants were categorized as having adequate sleep (≥7 h/d) or inadequate sleep (<7 h/d) on average across the week. Statistical interaction was also tested in a logistic model.

resultsMetS was identified in 49.8% of participants, and 56.6% had a mean sleep duration of <7 h/d. Neither higher adherence to the aMed diet nor sleep duration alone was associated with MetS. However, the stratified analysis showed that among women with inadequate sleep, higher adherence to the aMed diet was related to 16% lower odds of MetS (odds ratio: 0.84; 95% CI: 0.69, 0.99; P-interaction = 0.09).

conclusionsAssociations between diet and MetS are only observed in the presence of inadequate sleep duration, suggesting a potential interaction that warrants further investigation through longitudinal research.

Indexed as

Diet, MediterraneanMetabolic SyndromeSleepAdultFemaleHumansMexicoMiddle AgedSleep Durationalternate Mediterranean dietMediterranean dietmetabolic syndromemidlife womensleep duration

Identifiers

PMID40886950
PMCPMC12416764

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.