ArticleThe Journal of thoracic and cardiovascular surgery2026
Diagnostic yield of routine frozen section pathology examination of lymph nodes in lung resections for clinical stage IA non-small cell lung cancer.
Article in The Journal of thoracic and cardiovascular surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The cost of knowing: should frozen section pathology be used routinely for the assessment of lymph nodes in clinical stage IA non-small cell lung cancer?Journal of thoracic disease · 2026Article
- Utilizing intraoperative frozen section examination (IFSE) for diagnosis and treatment in a high-clinical-suspicion prostate cancer (PCa) cohort based onTranslational andrology and urology · 2026Article
- Outcome of segmentectomy vs. lobectomy in patients with cT1a-b N0 lung cancer and postoperative N1 upstaging.Langenbeck's archives of surgery · 2026Article
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13 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveIntraoperative identification of lymph node (LN) involvement by carcinoma has an impact on the surgical treatment of patients with clinical stage IA non-small cell lung cancer (NSCLC). This study aimed to identify the diagnostic performance of routine intraoperative frozen section pathology (FSP) evaluation of LNs in these patients.
methodsPatients with clinical stage IA NSCLC who underwent curative-intent lung resections between 2018 and 2023 were included. Pathology reports were retrospectively reviewed for data on LN evaluation and findings from FSP and final pathology. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for the detection of node-positive disease.
resultsOf 1008 patients who underwent surgery during the study period, 909 (90.2%) were included in this analysis. Nodal upstaging occurred in 46 patients (5.1%), corresponding to pN1 in 31 (3.4%) and to pN2 in 15 (1.7%). FSP detected patients with node-positive disease with a sensitivity of 80.4%, specificity of 99.9%, PPV of 97.4%, and NPV of 99.0%. Of the 7016 LNs analyzed, 95 (1.4%) were involved by carcinoma on final pathology. At the LN level, FSP detected nodal disease with a sensitivity of 83.2%, specificity of 100%, PPV of 98.8%, and NPV of 99.8%. Of 565 patients with a plan to undergo sublobar resection, 556 (98.4%) had all negative LNs on FSP; only 5 (0.9%) were found to have node-positive disease on final pathology.
conclusionsFSP performs well in detecting LN metastasis intraoperatively in patients with clinical stage IA NSCLC. FSP use should be considered as sublobar resections gain widespread application.
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