ArticleJournal of the American Medical Informatics Association : JAMIA2025
Prediction of postoperative infections by strategic data imputation and explainable machine learning.
Article in Journal of the American Medical Informatics Association : JAMIA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- End-of-surgery prediction of postoperative infectious complications from intraoperative vital-sign dynamics.NPJ digital medicine · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectivesInfections following healthcare-associated interventions drive patient morbidity and mortality, making early detection essential. Traditional predictive models utilize preoperative surgical characteristics. This study evaluated whether integrating postoperative laboratory values and their kinetics could improve outcome prediction. MATERIALS AND
methods91 794 surgical cases were extracted from electronic health records (EHR) and analyzed to predict bacterial infection as the endpoint. The endpoint was documented in the EHR as ICD-10 by a professional coding team. Variables were grouped as preoperative, intraoperative, or postoperative. Strategic imputation was used for postoperative missing laboratory values. Procedure-agnostic prediction models were built incorporating both static and kinetic properties of laboratory values.
resultsThe integration of kinetics of laboratory values into a machine learning predictor achieved a recall, precision and ROC AUC at postoperative day 2 of 0.71, 0.69, and 0.83, respectively. Moreover, infection detection outperformed clinician-based decision-making, as reflected by the postoperative timing of antibiotic administration. The analysis identified previously unknown, informative combinations of routine markers from hepatic, renal, and bone marrow functions that predict outcome. DISCUSSION: Dynamic modelling of postoperative laboratory values enhanced the timeliness and accuracy of infection detection compared with static or preoperative-only models. The integration of explainable machine learning supports clinical interpretation and highlights the contribution of multiple organ systems to postoperative infection risk.
conclusionA surgery-independent workflow integrating time-series values from laboratory parameters to enhance baseline predictors of infection. This interpretable approach is generalizable across procedures and has the potential to optimize patient outcomes and resource use in surgical care.
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