Evidence map›Paper›PMID 40886685›Full record

ArticleAddictive behaviors2025

Assessment of nicotine and cannabis co-use among adolescents and the association with nicotine and cannabis dependence symptoms.

Nikki S Jafarzadeh, Alyssa F Harlow, Claire A Walsh, Reid C Whaley, Dae-Hee Han, Adam M Leventhal, Jessica L Barrington-Trimis

Abstract read
In one paragraph

Article in Addictive behaviors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nikki S JafarzadehDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA; Institute for Addiction Science, University of Southern California Keck School of Medicine, Los Angeles, CA, USA. Electronic address: jafarzad@usc.edu.
Alyssa F HarlowDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA; Institute for Addiction Science, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Claire A WalshDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA; Institute for Addiction Science, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Reid C WhaleyDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA; Institute for Addiction Science, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Dae-Hee HanDepartment of Behavioral, Social and Health Education Sciences, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Adam M LeventhalDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA; Institute for Addiction Science, University of Southern California Keck School of Medicine, Los Angeles, CA, USA; Department of Psychology, University of Southern California, Los Angeles, CA, USA.
Jessica L Barrington-TrimisDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA; Institute for Addiction Science, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.

Funding

Vaping Nicotine and Cannabis Across Adolescence and Young AdulthoodR01CA229617 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BARRINGTON-TRIMIS, JESSICA LOUISE, LEVENTHAL, ADAM MATTHEW · 2019 to 2024
$4.3M
Tobacco Use Treatment Research for Vulnerable PopulationsK24DA048160 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Adam Matthew Leventhal · 2019 to 2026
$1.4M
The Tobacco and Cannabis Retail Environment, Neighborhood Disadvantage, and Adolescent VapingK01DA058084 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Alyssa Fitzpatrick Harlow · 2023 to 2026
$752k
Effect of Product Characteristics on the Abuse Liability of Nicotine PouchesK99DA058241 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAN, DAE HEE · 2024 to 2025
$312k
NCI NIH HHS R01 CA229617NIDA NIH HHS K01 DA058084NIDA NIH HHS K24 DA048160NIDA NIH HHS K99 DA058241
6 · The paper itself

Abstract

significanceAdolescent nicotine and cannabis co-use is common, but prior studies use imprecise measurement of co-use which may not capture the most problematic behaviors such as same-day use.

methodsThis cross-sectional study examined patterns of nicotine and cannabis co-use among Southern California high school students in Fall 2022 (N = 3823). Participants were classified into five mutually exclusive past-month nicotine and cannabis use groups: 1) same-day co-use: use of both substances on the same day at least once; 2) past-month co-use: use of both without same-day use; 3) exclusive nicotine use; 4) exclusive cannabis use; 5) no use of either. Adjusted logistic regression models evaluated the association of co-use with any nicotine and/or cannabis dependence symptoms.

resultsOverall, 3.3% reported same-day co-use, 1.5% past-month co-use, 1.6% exclusive nicotine use, 3.1% exclusive cannabis use, and 90.5% no nicotine/cannabis use. Odds of cannabis dependence symptoms (aOR = 4.28, 95%CI[1.98-9.28]) were higher among the same-day vs. past-month co-use group, as were odds of nicotine dependence (aOR = 1.81, 95%CI[0.87-3.77]), though the result was not statistically significant. Compared to past-month co-use, exclusive cannabis use was associated with similar odds of cannabis dependence symptoms (aOR = 0.99, 95%CI[0.47-2.09]), while exclusive nicotine use was associated with non-significant lower odds of nicotine dependence symptoms (aOR = 0.42, 95%CI[0.17-1.04]).

conclusionAdolescents reporting same-day co-use had significantly greater cannabis dependence symptoms than those reporting past-month but not same-day use of both substances. Using a same-day definition of co-use might capture more problematic co-use behaviors.

Indexed as

Marijuana AbuseTobacco Use DisorderAdolescentCaliforniaCross-Sectional StudiesFemaleHumansMaleAdolescentsCannabisCo-useNicotineSubstance dependence

Identifiers

PMID40886685
PMCPMC12581875

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.