ReviewSeminars in immunology2025
Gut mucosal immune responses - Implications for celiac disease and food allergy.
Review in Seminars in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
The intestinal mucosa employs a diverse set of defense mechanisms-from mucosal barrier regulation to immunoregulatory pathways-to maintain homeostasis despite constant exposure to microbial and dietary antigens. Failure to establish immune tolerance to food antigens can lead to pathological conditions such as celiac disease (CeD) and food allergies. This review provides an overview of the sequential processes that support tolerance to food antigens and examines how gene-environment interactions contribute to the pathogenesis of CeD and food allergies. Although the exact nature of the environmental triggers is unknown, microbial agents - whether bacterial or viral- are believed to play a critical role in disrupting homeostatic mechanisms in genetically predisposed individuals. Tolerogenic responses to dietary antigens can be compromised by environmentally induced local inflammation or epithelial barrier disruption, leading to the expansion of T helper 1 (T
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