ArticlePhysiological research2025
Effects of Astaxanthin on Chronic Exercise Fatigue.
Article in Physiological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Astaxanthin is a natural, small-molecule compound with anti-inflammatory and antioxidant properties that has broad potential for use in alleviating exercise fatigue. This study investigated whether astaxanthin can attenuate the onset of fatigue, prolong the time to exhaustion, and enhance post-exercise recovery using a rat model of chronic exercise fatigue. Twenty male rats were trained for 8 weeks to establish the chronic exercise fatigue model. During training, 10 rats were randomly assigned to receive astaxanthin intragastrically and 10 rats received soybean oil alone. After the intervention, 5 rats from each group were divided into astaxanthin (AX) and control groups. The remaining rats were divided into astaxanthin-exercise (AXE) and exercise control groups, respectively, and underwent exhaustive exercise. Astaxanthin alleviated chronic exercise fatigue by improving antioxidant capacity (^CAT, GSH-Px, GSH/GSSG; p<0.05-0.01) and mitochondrial function (^MMP, ST3/ST4; p<0.01-0.001). It prolonged exercise endurance (^time to exhaustion; p<0.001), reduced muscle damage (ˇBUN, CK; p<0.01) and accelerated recovery (^Liver glycogen, NEFA; p<0.001). Astaxanthin appears to improve skeletal muscle antioxidant capacity and mitochondrial function in chronic exercise fatigue in rats, providing a theoretical basis for fatigue management in exercise training.
Indexed as
Identifiers
40886374PMC12440312What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.