ArticlePhysiological research2025
Protective Effects of Teucrium Polium Leaf Ethanolic Extract Against Nicotine-Induced Nephrotoxicity in Mice.
Article in Physiological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- In vitro study and in silico reveal Teucrium Polium L. methanolic extract as an apoptosis inducer and a potential Bcl-2 inhibitor for breast cancer.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026Article
- Impact of Co-Supplementation of Gallic Acid With Vitamin C on Oxidant Stress, Inflammation, Hepatic and Renal Histology of Type 2 Diabetic Rats Induced With Fructose and Streptozotocin.Physiological research · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to examine the protective and antioxidant properties of a Teucrium polium leaf extract against acute kidney damage caused by nicotine in male mice. A total of 24 male Swiss albino mice were divided into four groups. The control group (oral solution of 0.9 % NaCl), the positive control group (injections of nicotine at a dosage of 2.5 mg/kg b.w.), the third group (received 100 mg/kg b.w. ethanolic extract of T. polium), and the fourth group (nicotine injections at a dosage of 2.5 mg/kg b.w + 100 mg/kg b.w. ethanolic extract of T. polium). GC-MS analysis of the plant extract revealed the presence of 16 active compounds. Nicotine administration resulted in a significant increase in kidney biomarkers, namely urea, uric acid, and creatinine, by 50 %, 207 %, and 129 %, respectively, compared to the control group, indicating nephrotoxicity. However, treatment with the T. polium extract improved these parameters by 77 %, 79 %, and 83 %, respectively. Furthermore, the nicotine group exhibited elevated levels of nitric oxide (NO) and malondialdehyde (MDA), which are indicators of oxidative stress, as well as decreased levels of glutathione (GSH) and reduced activity of superoxide dismutase (SOD). Conversely, the administration of the T. polium extract reversed these effects, suggesting its potential to enhance the antioxidant defense system. This finding was also supported by the improvements observed in the kidney TUNEL assay sections and the preservation of histopathological integrity. In conclusion, the T. polium extract demonstrates protective effects against nicotine-induced kidney damage by modulating oxidative stress and antioxidant defense mechanisms.
Indexed as
Identifiers
40886371PMC12440361What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.