Evidence map›Paper›PMID 40886314›Full record

ArticleCell reports2025

CD226 identifies effector CD8

Tomoyo Shinkawa, Evelyn Chang, Tasfia Rakib, Kelly Cavallo, Rocky Lai, Samuel M Behar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Tomoyo ShinkawaDepartment of Microbiology, University of Massachusetts Medical School, Worcester, MA, USA.
Evelyn ChangDepartment of Microbiology, University of Massachusetts Medical School, Worcester, MA, USA; Immunology and Microbiology Program, Graduate School of Biomedical Science, Worcester, MA, USA.
Tasfia RakibDepartment of Microbiology, University of Massachusetts Medical School, Worcester, MA, USA; Immunology and Microbiology Program, Graduate School of Biomedical Science, Worcester, MA, USA.
Kelly CavalloDepartment of Microbiology, University of Massachusetts Medical School, Worcester, MA, USA.
Rocky LaiDepartment of Microbiology, University of Massachusetts Medical School, Worcester, MA, USA.
Samuel M BeharDepartment of Microbiology, University of Massachusetts Medical School, Worcester, MA, USA. Electronic address: samuel.behar@umassmed.edu.

Funding

Regulation of CD8+ T cell immunity to tuberculosis (pending title)R01AI106725 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BEHAR, SAMUEL M · 2013 to 2022
$6.1M
Hypoxia, tuberculosis, and T cell dysfunctionR01AI172905 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SAMUEL M BEHAR · 2023 to 2026
$3.0M
PROTECTIVE CD8 T CELL RESPONSES to TUBERCULOSISR01AI192333 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SAMUEL M BEHAR · 2025 to 2026
$1.7M
BD FACSAriaTM Fusion Fluoresence-Activated Cell SorterS10OD028576 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SCHRADER, CAROL E · 2020 to 2020
$565k
NIAID NIH HHS R01 AI106725NIAID NIH HHS R01 AI172905NIAID NIH HHS R01 AI192333NIH HHS S10 OD028576
6 · The paper itself

Abstract

CD8

Indexed as

Antigens, Differentiation, T-LymphocyteCD8-Positive T-LymphocytesMacrophagesMycobacterium tuberculosisTuberculosisAnimalsGranzymesInterferon-gammaMiceMice, Inbred C57BLT Lineage-Specific Activation Antigen 1Antigens, Differentiation, T-LymphocyteGranzymesInterferon-gammaT Lineage-Specific Activation Antigen 1adaptive immunityantigen presentationCD226CD8 T cellsCP: ImmunologyCP: Microbiologyexhaustioninfectionin vivolungmouse modelsmycobacterium tuberculosis

Identifiers

PMID40886314
PMCPMC12536353

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.